Supervisor Database Search
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Full NameDr Annette Byrne
Dept of Physiology and Medical Physics
Royal College of Surgeons in Ireland
Webpage:rcsi.ie
Email Address:Email hidden; Javascript is required.
- cancer/oncology
- Surgery
- Pathology
- Gastroenterology
- Oncology
- Pharmacology
- Physiology
- Vascular Medicine
We are concerned with the pre-clinical development of novel targeted anti-cancer therapeutics and biomarkers with a particular interest in applying a multi-modality molecular imaging approach towards elucidation of drug mechanism of action in vivo. We also have a particular interest in the identification and screening of novel targets in vivo with specific expertise implementing PDX models. In addition we are also involved in the interrogation of new safety and efficacy biomarkers for clinically approved targeted therapies. Technologies include optical, nuclear, CT and MR imaging approaches and the development of imageable disease models. Our group works primarily on colorectal, brain and breast malignancies.
See URLs: www.coloforetell.ie; www.angiopredict.com; www.breastpredict.com
Example Publication:
O'Halloran PJ, Viel T, Murray DW, Wachsmuth L, Schwegmann K, Wagner S, Kopka K, Jarzabek MA, Dicker P, Hermann S, Faber C, Klasen T, Schafers M, O'Brien D, Prehn JH, Jacobs AH, Byrne AT. Mechanistic interrogation of combination bevacizumab/dual PI3K/mTOR inhibitor response in glioblastoma implementing novel MR and PET imaging biomarkers.
Eur J Nucl Med Mol Imaging 2016 Aug;43(9):1673-83.