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Full NameProfessor Darran O'Connor
Molecular and Cellular Therapeutics
Royal College of Surgeons in Ireland
Webpage:rcsi.ie
Email Address:Email hidden; Javascript is required.
- genetics, genomics and molecular biology
- infectious disease and the immune system
- cancer/oncology
- Medicine
- Surgery
- Obstetrics and Gynaecology
- Pathology
- Endocrinology
- Gastroenterology
- Immunology
- Oncology
- Pharmacology
The Molecular Oncology Laboratory at the Dept. of Molecular & Cellular Therapeutics is a vibrant, well funded and dynamic research group with extensive experience in the discovery of molecular determinants of cancer progression (via transcriptomic/proteomic/genomic profiling and functional genomic screening) and their clinical translation through the development and analysis of tissue microarrays, in addition to functional analysis using in vitro models and xenograft studies utilising small animal imaging approaches. As such, we have established an integrated workflow for the molecular and clinical analysis of central tumourigenic processes that we are currently applying to a number of different tumour types, with a strong emphasis on breast and colon cancer.
The lab is part of the Irish Cancer Society-funded Breast-Predict cancer centre (www.breastpredict.com) and has participated in major international research programmes such as the FP7 RATHER (www.ratherproject.com) and Angiopredict (www.angiopredict.com) consortia. Funded by Science Foundation Ireland and the Irish Cancer Society, our current focus is on the development of novel decision support tools for clinicians and the characterisation of dynamic changes that occur in tumours during therapy, including the role of infiltrating lymphocytes in determining response to treatment.