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Full NameProfessor Mark Cunningham

Discipline of Physiology

Trinity College Dublin

Email Address:Email hidden; Javascript is required.

Research Fields
  • physiology and non-communicable disease
  • cancer/oncology
  • neuroscience and mental health
Postgrad Medical Specialties
  • Medicine
  • Surgery
  • Psychiatry
  • Pathology
Medical Subspecialties
  • Dementia
  • Immunology
  • Neurology
  • Neurophysiology
  • Neuropsychiatry
  • Oncology
  • Pharmacology
  • Physiology
My Work

The Cunningham research group works to gain a better understanding of the mechanisms that contribute to the generation of organised electrical activity in the brain in health and disease states. In the lab we primarily use electrophysiology to study the mechanisms by which neuronal microcircuits give rise to neuronal oscillations in the brain. Our work has implications for conditions such as neurodegeneration and schizophrenia. The lab has a particular interest in understanding how pathological electrical activity arises in the epileptic brain and we use our approaches to develop better treatments for epilepsy.

Chan F, Lax NZ, Voss CM, Aldana BI, Whyte S, Jenkins A, Nicholson C, Nichols S, Tilley E, Powell Z, Waagepetersen HS, Davies CH, Turnbull DM, Cunningham MO. The role of astrocytes in seizure generation: insights from a novel in vitro
seizure model based on mitochondrial dysfunction. Brain. 2019 doi: 10.1093/brain/awy320.

Augustin K, Williams S, Cunningham M, et al. Perampanel and decanoic acid show synergistic action against AMPA receptors and seizures. Epilepsia. 2018;59(11):e172-e178. doi:10.1111/epi.14578

Stone TJ, Rowell R, Jayasekera BAP, Cunningham MO, Jacques TS. Review: Molecular characteristics of long-term epilepsy-associated tumours (LEATs) and mechanisms for tumour-related epilepsy (TRE). Neuropathol Appl Neurobiol. 2018 doi: 10.1111/nan.12459.

Jones RS, da Silva AB, Whittaker RG, Woodhall GL, Cunningham MO. Human brain slices for epilepsy research: Pitfalls, solutions and future challenges. J Neurosci Methods. 2016 doi: 10.1016/j.jneumeth.2015.09.021.