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Full NameProfessor Paul McLoughlin

Conway Institute

University College Dublin

Webpage:people.ucd.ie

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Research Fields

physiology and non-communicable disease
bioengineering/medical devices

Postgrad Medical Specialties

Medicine
Surgery
Anaesthetics
Paediatrics
Pathology

Medical Subspecialties

Cardiology
Physiology
Respiratory Medicine
Vascular Medicine

My Work

Our research explores key mechanisms in the development and progression of chronic hypoxic lung diseases characterized by inflammation and pulmonary fibrosis.

We have shown that a specific family of proteins, known as the bone morphogenetic antagonists, plays a major role in the development of hypoxic pulmonary hypertension (WHO Group 3 PH) and more recently we have shown that these proteins also contribute to the development of idiopathic pulmonary fibrosis (1-3). We are currently exploring the molecular pathways through which one of the most important members of this family (gremlin 1) acts (4).

A second research focus is altered endothelial barrier function and the development of pulmonary oedema in diseases such as ARDS and systemic sepsis. Interestingly, this work also has the potential to improve the supply of donor lungs for transplant by enhancing ex vivo machine perfusion strategies (5).

1. Cahill et al. Circulation. 2012 Feb 21;125(7):920-30. PMID: 22247494
2. Murphy et al. Am J Pathol. 2016 Mar;186(3):600-15. PMID: 26765958
3. Rowan et al. Lancet Respir Med. 2016 Mar;4(3):225-36. PMID: 26895650
4. Rowan et al. Pulm Circ. 2018 Oct 4:2045894018807205. doi: 10.1177/2045894018807205. PMID: 30284507
5. Rowan et al. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L476-L484. PMID: 29792349