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Full NameProfessor Oliver FitzGerald
Medicine
University College Dublin
Webpage:www.ucd.ie
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- genetics, genomics and molecular biology
- infectious disease and the immune system
- Medicine
- Rheumatology
Prof. FitzGerald has published more than 300 peer reviewed papers, many on the subject of inflammatory arthritis, in particular psoriatic arthritis. His main research interests in psoriatic arthritis include clinical and therapeutic studies; analysis of synovial and skin cellular and cytokine profiles, and, more recently, genetic and proteomic studies focused on trying to understand the molecular basis of disease heterogeneity and treatment response.
We have shown that certain HLA antigens are not only contributing to disease susceptibility but are also important in determining clinical characteristics such as the duration between onset of skin psoriasis and arthritis or whether a patient has symmetrical or asymmetrical sacroiliac involvement. Using a proteomic approach in collaboration with Prof. Steve Pennington at the Conway Institute, UCD our current focus is exploring whether these genotypes initiate qualitatively different immune responses. We are using several different platforms (Luminex, LC-MS/MS and SomaScan) to examine this question.
We are also establishing additional patient cohorts which using a similar proteomic approach will address questions such as how to predict disease development or how to predict treatment response.