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Full NameProfessor Jonathan Bond
School of Medicine
University College Dublin
Webpage:www.ucd.ie
Email Address:Email hidden; Javascript is required.
- genetics, genomics and molecular biology
- cancer/oncology
- Other
Paediatric; Haematology; Leukaemia; Epigenetics
- Medicine
- Paediatrics
- Pathology
- Adolescent medicine
- Haematology
- Oncology
Our research is co-located at Systems Biology Ireland (SBI) in UCD and Children's Health Ireland (CHI) at Crumlin. Our aim is to unravel the molecular pathogenesis of high-risk childhood and adolescent leukaemias and lymphomas using systems biology approaches. We are particularly interested in understanding how acquired somatic genetic alterations alter leukaemia biology and outcome (for recent examples see PMID 31940477, 30655366, 29950694, 28605290, 28196984).
Our main current focus is working out the downstream molecular effects of mutations and deletions in epigenetic factors, using a combination of in vitro cell line experiments and computational modelling. Co-location in the National Paediatric Haematology Oncology service at CHI means that our research is tightly tied to the clinic, helping us to ask relevant scientific questions that are important for patient care. These links also mean that we are well placed to extend our analyses to primary leukaemia samples at CHI and under the framework of international clinical trials. For example, I sit on the scientific committee and chair the Biobanking committee of the ALLTogether01 study, which will be the largest childhood leukaemia trial ever undertaken (2500 cases/year across Europe).