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Full NameProfessor Dan Longley
Patrick Johnston Centre for Cancer Research
Queen's University Belfast
- clinical trials
My research is focussed on the extrinsic apoptotic pathway regulated by death receptors. In particular, my work investigates the predictive, prognostic and therapeutic relevance of the caspase 8 inhibitor FLIP and the inhibitor of apoptosis proteins (IAPs). We have shown that FLIP and IAPs are key regulators of death receptor-, chemotherapy- and radiation-induced apoptosis in a range of in vitro and in vivo cancer models. Based on this work (accepted for publication in Mol Cancer Therapeutics), we are currently planning a phase-I clinical trial to examine the combination of a novel IAP inhibitor tolinapant (Astex Pharmaceuticals) with standard-of-care chemotherapy (FOLFOX) in metastatic colorectal cancer.