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Full NameProfessor Dan Longley
Patrick Johnston Centre for Cancer Research
Queen's University Belfast
- clinical trials
Postgrad Medical Specialties
My research is focussed on the extrinsic apoptotic pathway regulated by death receptors. In particular, my work investigates the predictive, prognostic and therapeutic relevance of the caspase 8 inhibitor FLIP and the inhibitor of apoptosis proteins (IAPs). We have shown that FLIP and IAPs are key regulators of death receptor-, chemotherapy- and radiation-induced apoptosis in a range of in vitro and in vivo cancer models. Based on this work (accepted for publication in Mol Cancer Therapeutics), we are currently planning a phase-I clinical trial to examine the combination of a novel IAP inhibitor tolinapant (Astex Pharmaceuticals) with standard-of-care chemotherapy (FOLFOX) in metastatic colorectal cancer.