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Full NameDr Amanda McCann
University College Dublin
Senescence, Chemoresistance, Extracellular Vesicles/exosomes, Breast Cancer
Amanda McCann is a PI and UCD Conway Fellow in the UCD Conway Institute of Biomolecular and Biomedical Science. She is also Associate Professor and Head of Pathology in the UCD School of Medicine and Academic Lead on the establishment of the UCD Academic Centre in Translational Oncology (ACTO). She is also a founding member of the International Cell Senescence Association (ICSA) http://www.cellsenescence.info/
Her group's specific area of interest is to decipher how cancer cells can maintain viability via cellular senescence in the face of chemotherapy, particularly in the space of triple negative breast cancer and high grade serous ovarian cancer. Cellular senescence is a viable cellular fate mechanism which although non-replicative, is highly metabolically active producing a wealth of cytokines and an increased release of extracellular vesicles/exosomes that impact directly on the tumour microenvironment (TME). Tumour hypoxia integral to chemoresistance and indeed chemotherapeutic agents such as the taxanes and platinums used in the portfolio of drugs in the TNBC and ovarian cancer setting can also induce senescence. Her group and others believe that the eradication of senescent cells will ensure a more efficacious patient response to chemotherapy.