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Full NameProfessor Denise Fitzgerald

Wellcome-Wolfson Institute for Experimental Medicine

Queen's University Belfast

Webpage:qub.ac.uk

Email Address:Email hidden; Javascript is required.

Research Fields
  • infectious disease and the immune system
  • cell and developmental biology/regenerative medicine
  • neuroscience and mental health
Postgrad Medical Specialties
  • Psychiatry
  • Ophthalmology
  • Paediatrics
  • Pathology
  • Public Health
Medical Subspecialties
  • Adolescent medicine
  • Dementia
  • Immunology
  • Neurology
  • Neurophysiology
  • Neuropsychiatry
  • Physiology
My Work

The Fitzgerald lab is a Regenerative NeuroImmunology research group at QUB with a particular focus on Multiple Sclerosis (MS), an immune-mediated, demyelinating disorder of the Central Nervous System (CNS). The central goal of our research is to identify new strategies to treat MS and other inflammatory and demyelinating conditions.

We are particularly interested in the process of myelin repair (remyelination) and aim to identify novel therapeutic targets to promote remyelination in MS. To address this goal, we are uncovering new cellular and molecular cues from the immune system that influence the response to neurological damage and promote successful progenitor cell maturation to repair damaged tissue. We also conduct a research programme on the pathogenesis of autoimmune inflammation with an emphasis on T cell biology.

Our hard-working team consists of scientists from the fields of Neuroscience, Regenerative Biology and Immunology who work together to study neuro-immune cellular communication and interaction, supported by international collaborators including in Ophthalmology. Through our research we are gaining new insights into the influence of the immune system and inflammation on demyelination and remyelination in the CNS.

Regulatory T cells promote myelin regeneration in the central nervous system. Dombrowski Y, et al., Nature Neuroscience. 2017 May;20(5):674-680. doi: 10.1038/nn.4528.

https://www.facebook.com/TheFitzgeraldGroup1/