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Full NameProfessor Richard Kennedy

CENTRE FOR CANCER RESEARCH AND CELL BIOLOGY

Queen's University Belfast

Webpage:qub.ac.uk

Email Address:Email hidden; Javascript is required.

Research Fields
  • genetics, genomics and molecular biology
  • cancer/oncology
  • Other
Other Research Fields:

Immune checkpoint PD-L1 cGAS STING "DNA Repair"

Postgrad Medical Specialties
  • Medicine
  • Pathology
Medical Subspecialties
  • Immunology
  • Oncology
  • Pharmacology
My Work

The Kennedy lab was the first to describe how genomic instability in cancer activates the cGAS-STING pathway through accumulation of cytoplasmic DNA. This results in the release of cytokines that attract lymphocytes into tumours. The cGAS-STING pathway is now known to be important in the response to novel cancer therapeutics that use the immune system to fight cancer such as PD-L1 inhibitors. The lab continue to investigate the mechanisms that activate the cGAS-STING pathway and how these can be harnessed to enhance the immune response to cancer.

Relevant publication:
https://pure.qub.ac.uk/portal/files/121087004/JNCI_J_Natl_Cancer_Inst_2017_Parkes_.pdf