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Full NameProfessor David J Williams

Geriatric and Stroke Medicine

Royal College of Surgeons in Ireland

Webpage:rcsi.com

Email Address:Email hidden; Javascript is required.

Research Fields

epidemiology/population health research
clinical trials
Other

Other Research Fields:

Epidemiology/Population Health Research

Postgrad Medical Specialties

Medicine
Public Health

Medical Subspecialties

Cardiology
Dementia
Neurology
Pharmacology
Vascular Medicine

My Work

The research interests of the Department of Geriatric and Stroke Medicine include Pharmacoepidemiology and Patient Safety, Stroke and Vascular Medicine. In collaboration with the Department of Psychology the Department led a 2-year Health Research Board (HRB) funded project (ASPIRE-S) which assessed adherence to the secondary preventive measures and rehabilitation guidelines in patients with Ischaemic Stroke. We are currently completing a follow-up study to assess 5-year outcome. The department has a particular interest in the effect of stroke on cognitive outcome. The department collaborated on the ESCAPE study, a multicentre international study, the purpose of which was to understand whether endovascular clot removal can be added to the current standard of care to improve outcome from stroke.

In the field of patient safety, the Department also led the first study of adverse events (INAES) in Ireland and we have recently been provided with funding to complete a follow-up study (INAES-2). We are currently completing a study on the rate of admisions to hospital due to adverse drug reactions (ADRs) in older patients.

I am a co-director with Prof Peter Kelly of the Irish Stroke Clinical Trials network (https://hrb-sctni.ie/) which is co-ordinating a number of trials in the stroke field.

Relevant publications
1.Holodinsky JK, Patel AB, Thornton J, Kamal N, Jewett LR, Kelly PJ, Murphy S, Collins R, Walsh T, Cronin S, Power S, Brennan P, O'hare A, McCabe DJ, Moynihan B, Looby S, Wyse G, McCormack J, Marsden P, Harbison J, Hill MD, Williams D. Drip and ship versus direct to endovascular thrombectomy: The impact of treatment times on transport decision-making.Eur Stroke J. 2018 Jun;3(2):126-135. doi: 10.1177/2396987318759362. Epub 2018 Feb 14
2.Gaynor E, Williams D et al. Cognitive Impairment, Vulverability, and Mortality Post Ischaemic Stroke: A Five- Year Follow-Up of the Action on Secondary Prevention Interventions and rehabilitation in Stroke (ASPIRE-S) Cohort. J Stroke Cerebrovasc Dis.2018 May 23
3.Rafter N, Hickey A, Conroy RM, Condell S, O’Connor P, Vaughan D, Walsh G, Williams DJ. The Irish National Adverse Events Study (INAES): the frequency and nature of adverse events in Irish hospitals-a retrospective record review study. BMJ Qual Saf. 2016 Feb 9
4.Goyal M, Demchuk A, Menon B, Eesa M, Rempel J, Thornton J, Roy D, Jovin T, Willinsky R, Sapkota B, Dowlatshahi D, Frei D, Kamal N, Montanera W, Poppe A, Ryckborst K, Silver F, Shuaib A, Tampieri D, Williams D, Bang O, Baxter B, Burns P, Choe H, Heo Ji-Hoe, Holmstedt C, Jankowitz B, Kelly M, Linares G, Mandzia J, Shankar J, Sohn S ,Swartz R, Barber P, Coutts S, Smith E, Morrish W, Weill A, Subramaniam S, Mitha A, Wong J, Lowerison M, Tolulop S, and Hill M for the ESCAPE Trial Investigators. Randomised Assessment of Rapid Endovascular Treatment of Ischaemic Stroke N Engl J Med 2015;372:1019-1030.