Supervisor Database Search
Search for supervisors below. You can filter your search using the options and select
multiple fields by holding CTRL (Cmd on Mac) + clicking multiple options in a list.
The ICAT Supervisor list is reviewed annually by the partner universities and updated online in March/April each year. You can read the ICAT supervisor policy here.
Full NameProfessor Leonie Young
Department of Surgery
Royal College of Surgeons in Ireland
Webpage:rcsi.com
Email Address:Email hidden; Javascript is required.
- cancer/oncology
- Medicine
- Surgery
Our programme of research is focused on uncovering networks involved in mediating resistance in ER-positive breast cancer, and in doing so identify markers to predict endocrine sensitivity and importantly develop new therapeutic targets.
Our approach is to focus on transcriptional networks, harnessing data from high throughput experimental methods including RNAseq, Methylseq, ChIPseq, molecular studies and translational studies. We are capitalising on our established strengths in translational research, in particular making use of cultures derived from patient tumours, PDX models and clinical datasets. This allows us to model the mechanism(s) of resistance and define new predictive markers and therapeutic targets.
- Vareslija D, McBryan J, Fagan A, Redmond AM, Hao Y, Sims AH, Turnbull A, Dixon JM, Ó Gaora P, Hudson L, Purcell S, Hill AD, Young LS. Adaptation to AI Therapy in Breast Cancer Can Induce Dynamic Alterations in ER Activity. Clin Cancer Res. 2016 1;22(11):2765-77
- McBryan J, Fagan A, McCartan D, Bane FT, VareSlija D, Cocchiglia S, Byrne C, Bolger J, McIlroy M, Hudson L, Tibbitts P, Gaora PÓ, Hill AD, Young LS. Transcriptomic Profiling of Sequential Tumors from Breast Cancer Patients Provides a Global View of Metastatic Expression Changes. Clin Cancer Res. 2015 1;21(23):5371-9.