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Full NameDr Nollaig Bourke
School of Medicine
Trinity College Dublin
- genetics, genomics and molecular biology
- infectious disease and the immune system
- physiology and non-communicable disease
- Geriatric Medicine
- Infectious diseases
- Vascular Medicine
My research aims to determine novel biomarkers of health and disease in ageing, as well as elucidating cellular mechanisms that drive the enhanced systemic inflammation that often occurs with ageing (“inflammageing”). My research focuses on investigating the specific innate immune signalling pathways, particularly type I interferon and inflammasome signalling, that result in pathological inflammation and decreased immunity in older adults. I collaborate with many clinical and scientific colleagues and my lab is now exploring the dysregulation of these mechanisms across specific disease states associated with accelerated ageing and/or pathological inflammation e.g. HIV, ANCA-associated vasculitis, type II diabetes, cancer.