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Full NameProfessor Mark Little

Trinity Health Kidney centre

Trinity College Dublin

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Research Fields
  • infectious disease and the immune system
  • cell and developmental biology/regenerative medicine
  • epidemiology/population health research
Postgrad Medical Specialties
  • Medicine
  • Pathology
  • Public Health
Medical Subspecialties
  • Health Informatics
  • Immunology
  • Nephrology
  • Physiology
  • Rheumatology
  • Vascular Medicine
My Work

The Trinity Health Kidney Centre is an academic health science centre comprising the academic department of Nephrology in Trinity College Dublin and the clinical nephrology units in St James's and Tallaght Hospitals. Research is driven through several strands:

1. Renal Inflammation Group, a translational medicine programme focused on investigation of pathogenesis and discovery of biomarkers of disease in autoimmune disease. The principal research interest is in ANCA vasculitis, an autoimmune condition that causes multi-organ failure as a consequence of overwhelming necrotising inflammation affecting small blood vessels. To assist in answering these questions, we have set up infrastructure that allows collection of longitudinal clinical data in the form of a national registry and biobank (, which is linked to a basic science laboratory.

2. Chronic Disease Informatics group (, a trans-disciplinary unit that combines Nephrology, computer science and statistics to address research questions related to autoimmune and kidney disease using novel data science methodologies. We are linked closely with the ADAPT SFI centre (

3. Translational Immunology Research Group, a molecular biology laboratory with expertise in cell signalling, immune evasion and cellular immunology