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Full NameProfessor Sabine Koelle
Department:School of Medicine
Organisation:University College Dublin
Other Research Fields:
Postgrad Medical Specialties
- Obstetrics and Gynaecology
Professor Koelle`s research is focused on reproductive medicine, especially on improving the results of assisted reproduction. Recent research projects include the mechanisms of gameto-maternal interaction, embryo-maternal communication and early embryogenesis in humans and animals. Additionally she is establishing new criteria for functional sperm and oocyte assessment and is developing new methods for in vivo imaging of fertilization and early embryogenesis in the female genital tract.
Novel concepts for improving life quality in women affected by endometriosis
Worldwide more than 10.8 million women are affected by endometriosis. 35-50 % of all women experiencing chronic pelvic pain and infertility are diagnosed with this disease which is characterized by growth on the endometrium outside the uterus. To date the cause of endometriosis remains unclear - the theories of retrograde menstruation or of an autoimmune disease have not been able to explain all instances of endometriosis. Current therapeutic measures are temporary and insufficient. Therefore the aim of this study is to shed light on the pathomechanisms of this disease and to establish innovative concepts for causal and effective treatment.
For this purpose we will elucidate the molecular mechanisms of endometriosis in the female genital tract by novel imaging technologies such as digital live cell imaging (LCIS) as well as by confocal laser scanning microscopy (CLSM), scanning electron microscopy (SEM) and molecular histochemical analyses. The expected outcome of the study is to shed light on the pathomechanisms of endometriosis. This knowledge is pivotal in order to establish novel concepts for relieving chronic pain and restoring fertility - thus distinctly improving quality of life in affected patients.