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October 3, 2016
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Dr Marguerite Clyne

Department:School of Medicine

Organisation:University College Dublin

Webpage:https://www.ucd.ie/medicine/ourresearch/researchgroups/mucosalpathogensgroup/Groups_MucosalPathogens.pdf

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Research Fields
  • infectious disease and the immune system
Postgrad Medical Specialites
  • Medicine
  • Paediatrics
Medical Subspecialties
  • Gastroenterology
  • Infectious diseases
My Work

My area of interest is bacterial interactions with human and animal tissue. Bacteria that we work with include Helicobacter pylori, which causes duodenal ulcers, Campylobacter jejuni a common cause of food poisoning and Pseudomonas aeruginosa, an opportunistic human pathogen that infects Cystic Fibrosis patients. An area of particular interest is how bacteria colonise and live in mucus. We have developed a number of cell culture systems to learn how bacteria colonise mucus and interact with different components of mucus. Such knowledge can lead to the development of novel therapeutics that can prevent infection

Relevant publications from the group include

Dunne C, et al. Factors that mediate colonization of the human stomach by Helicobacter pylori. World J Gastroenterol. 2014 May 21;20(19):5610-24.

Montefusco S, et al Copper promotes TFF1-mediated Helicobacter pylori colonization. PLoS One. 2013 Nov 13;8(11):e79455

Naughton JA, et al. Divergent mechanisms of interaction of Helicobacter pylori and Campylobacter jejuni with mucus and mucins. Infect Immun. 2013 Aug;81(8):2838-50.

Dolan B, et al. The interaction of Helicobacter pylori with the adherent mucus gel layer secreted by polarized HT29-MTX-E12 cells. PLoS One. 2012;7(10):e47300.

Reeves EP et al . Helicobacter pylori lipopolysaccharide interacts with TFF1 in a pH-dependent manner. Gastroenterology. 2008 Dec;135(6):2043-54, 2054.e1-2.

Potential Projects

Potential Research Projects
1. Development of biologically relevant cell culture model systems to assess the interaction of pathogens with host cells and mucosal surfaces.
2. Assessing commensal colonisation of chickens by the human pathogen Campylobacter jejuni using transcriptomics and proteomics in order to develop strategies to reduce the burden in chickens and hence infection of humans.
3. The effect of pathogens on processing of human mucins.
4. The effect of environmental conditions on virulence in the opportunistic pathogen Pseudomonas aeruginosa.