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• genetics, genomics and molecular biology
• physiology and non-communicable disease
• epidemiology/population health research

• Medicine
• General Practice
• Public Health

• Cardiology
• Clinical Trials
• Community Medicine
• Dementia
• Endocrinology
• Geriatric Medicine
• Pharmacology
• Physiology
• Vascular Medicine

Alice Stanton is a clinician-scientist. She is currently Professor in Cardiovascular Pharmacology and Director of Intermediate Cycle of the Medical School at the Royal College of Surgeons in Ireland, Consultant in Hypertension Medicine at Beaumont and the National Maternity Hospitals, Dublin, and Fellow of the Royal Colleges of Physicians in Ireland.
Particular research interests include; management of resistant hypertension, non-invasive measurement of the vasculature, cardiovascular genetics, personalized medicine and most recently the impact of micronutrients on health and wellbeing. She has had grants and fellowships from the Health Research Board (Ireland), Enterprise Ireland, the Higher Education Authority (Ireland), the Irish Heart Foundation the British Heart Foundation, Engineering Physical Science Research Council (UK), Medical Research Council (UK) and the European Commission Seventh Framework Programme. She has authored in excess of 100 peer-reviewed published papers including the following recent publications;
? Lobo MD, Sobotka PA, Stanton A, Cockcroft JR, Sulke N, Dolan E, van der Giet M, Hoyer J, Furniss SS, Foran JP, Witkowski A, Januszewicz A, Schoors D, Tsioufis K, Rensing BJ, Scott B, Ng GA, Ott C, Schmieder RE; for the ROX CONTROL HTN Investigators. Central arteriovenous anastomosis for the treatment of patients with uncontrolled hypertension (the ROX CONTROL HTN study): a randomised controlled trial. Lancet. 2015 Apr 25;385(9978):1634-41. PMID: 25620016.
? McCarthy NS, Vangjeli C, Cavalleri GL, Delanty N, Shianna KV, Surendran P, O'Brien E, Munroe PB, Masca N, Tomaszewski M, Samani NJ, Stanton AV. Two Further Blood Pressure Loci Identified in Ion Channel Genes with a Genecentric Approach. Circ Cardiovasc Genet. 2014 Dec;7(6):873-9. PMID: 25210050.
? Simon Thom, Neil Poulter, Jane Field, Anushka Patel, Dorairaj Prabhakaran, Alice Stanton, Diederick E. Grobbee, Michiel L. Bots, K. Srinath Reddy, Raghu Cidambi, Severine Bompoint, Laurent Billot, Anthony Rodgers for the UMPIRE Collaborative Group. Effects of a fixed dose combination-based strategy on medication adherence, blood pressure and cholesterol levels in patients with cardiovascular disease or similarly high risk: the UMPIRE randomised controlled trial. JAMA. 2013 Sept;310(9):918-929. PMID: 24002278

Consumption of long chain marine derived omega-3 polyunsaturated fatty acids (Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA)) have beneficial effects on cardiovascular, brain and muscle health. However, due to poor dietary habits many people worldwide demonstrate deficiencies in these essential micronutrients. Natural enrichment of EPA and DHA in foods that are commonly consumed, such as chicken and eggs, is an attractive solution. Recent research by Devenish and Prof Stanton's group led to the development of an omega-3 enriched poultry feed (OmegaPro-Poultry). Chickens fed with OmegaPro-Poultry have four-fold increments in chicken-meat EPA and DHA. Humans eating the resultant chicken-meat demonstrate significant increases in plasma EPA and DHA, and also demonstrate cardiovascular benefits. Omega-3 enriched eggs are already commercially available. In a randomized controlled nutritional trial in 160 elderly volunteers, with and without mild cognitive impairment, we plan to test the effects of consumption of omega-3 enriched chicken-meat and eggs on brain size, cognitive function, mood, muscle mass and strength. A nutrigenomics substudy is also planed, testing if benefits vary with genotype. This project has considerable potential to improve human quality of life and longevity, and would provide excellent training for clinicians interested in Cardiovascular Medicine, Clinical Pharmacology, Care of the Elderly,
Public Health, Genetics, Nutrition or Endocrinology.