Supervisor View Full Details 2nd

• Other

Obstetrics, neonatology, early paediatrics

• Obstetrics and Gynaecology
• Paediatrics
• Public Health

• Clinical Trials
• Neonatology
• Other

Obstetrics, maternal fetal medicine

Prof Malone is chairman of two national networks in the perinatal space, together with his team at the RCSI Dept of Obstetrics & Gynaecology at the Rotunda Hospital. Perinatal Ireland is a multi-centre, all-Ireland research consortium focussed on carrying out research into women's and children's health that links the 7 major academic obstetric hospitals and 7 medical schools across the island of Ireland.

In September 2014, funding for the HRB Mother & Baby Clinical Trials network (CTN) was announced, an exciting and unique partnership between the two most successful perinatal research entities currently operational in Ireland, INFANT (UCC) and Perinatal Ireland (RCSI).This network, through its partners and collaborators has a well-established record in collaborative research and in conducting large-scale, multicentre, randomised controlled trials and builds on the world class expertise and strengths of its partners and people, with a core focus on developing novel interventions and diagnostics in pregnancy and neonates. The HQ of this network is based in RCSI at the Rotunda and the suite of trials and research programme is managed and coordinated from here.

http://www.perinatalireland.ie

The initial work programme for the HRB MB-CTNI involves the implementation of a number of large scale multi centre Randomised Controlled Trails (RCT) including the PARROT RCT, which explores measuring plasma PIGF in women who present with suspected pre-eclampsia, as well as a suite of other pilot and feasibility studies including; MINT (pilot study for trial of milrinone therapy in new-borns with PPHN)and IRELAND (pilot study investigating the role of Aspirin in the pregnancy outcome of women with pre-gestational diabetes). The IRELAND study team was recently awarded significant funding for a subsequent main RCT to be rolled out in 6 sites nationally which will commence in late 2017.

Prof Malone’s team are also coordinating a number of other international RCTS and studies around venous thromboembolism (VTE) in pregnancy, maternal hemodynamics, ultrasound at term, multiple gestation, growth restriction etc.