Supervisor View Full Details 2nd

Supervisor View Full Details
October 11, 2016
Fellowship Call for 2019
October 12, 2018
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Full NameProfessor Carel LeRoux

Department:Diabetes Complications Research Centre

Organisation:University College Dublin

Webpage:www.ucd.ie

Email Address:Email hidden; Javascript is required.

Research Fields
  • physiology and non-communicable disease
  • cancer/oncology
  • neuroscience and mental health
Postgrad Medical Specialties
  • Medicine
  • Surgery
  • Obstetrics and Gynaecology
  • Pathology
  • Sports and Exercise Medicine
Medical Subspecialties
  • Cardiology
  • Endocrinology
  • Gastroenterology
  • Nephrology
  • Oncology
  • Physiology
  • Other
Other Medical Specialties:

Surgery

My Work

We are interested in how the gut talks to the brain to impact on intentional and unintentional weight loss. We are also interested in how intentional weight loss can be used to improve the complications of obesity including diabetes, diabetic kidney disease, obesity related cancers, cardiovascular disease and infertility. These questions have resulted in high impact papers that helped change clinical care pathways:

le Roux CW, et al. 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial. Lancet. 2017 Apr 8;389(10077):1399-1409.

Miras AD, le Roux CW. Metabolic Surgery in a Pill. Cell Metab. 2017 May 2;25(5):985-987.

Pi-Sunyer X, le Roux CW et al. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med. 2015 Jul 2;373(1):11-22.
Elliott J, le Roux CW et al. Gut Hormone Suppression Increases Food Intake After Esophagectomy With Gastric Conduit Reconstruction. Ann Surg. 2015 Nov;262(5):824-29.

Potential Projects

We have several projects available, these include:

1. Understanding unintentional weight loss after upper gastrointestinal surgery with curative intent for oesophageal cancer. This project will allow the Clinical Fellow to learn new methodologies while also being clinically active in managing patients throughout their journey. Methods include functional MRI, behaviour tests, and laboratory measurement techniques.

2. Exploring how intentional weight loss can be used to control endometrial cancer. This project will allow the Clinical Fellow to learn about pharmacological and surgical approaches to obtain more than 15% weight loss in patients who have endometrial cancer but who want to preserve fertility. This project also have an component that uses BD II Han rats to allow a truly translational approach between the bench and the bedside.

3. Reversing diabetic kidney disease. This project will allow the Clinical Fellow to use both animal and human models to understand how intentional weight loss can reverse the damage to the podocyte caused type 2 diabetes