Supervisor View Full Details 2nd

• genetics, genomics and molecular biology
• infectious disease and the immune system
• epidemiology/population health research

• Medicine
• Anaesthetics
• Emergency Medicine

• Clinical Trials
• Health Informatics
• Infectious diseases
• Immunology
• Respiratory Medicine

My group has an special focus on the interdisciplinary research group focusing on clinical and translational research in critical illness

Major research domains include:

Sepsis and acute lung injury
Organ dysfunction, support, and recovery
Translational medicine in critical care
Precision medicine and predictive analytics
Severe infections in critical care

Selected publications
1.Martin-LoechesIetal.Increasedincidenceofco-infectionincriticallyillpatientswithinfluenza.Intensive Care Med. 2017
2. Martin-Loechesetal.Potentiallyresistantmicroorganismsinintubatedpatientswithhospital-acquired
pneumonia: the interaction of ecology, shock and risk factors. Intensive Care Med. 2013
3. Martin-Loechesetal.UseofearlycorticosteroidtherapyonICUadmissioninpatientsaffectedby severe pandemic (H1N1)v influenza A infection. Intensive Care Med 2010.
4. Martin-Loechesetal.Theprotectiveassociationofendogenousimmunoglobulinsagainstsepsis
mortality is restricted to patients with moderate organ failure. Ann Intensive Care. 2017
5. Martin-Loechesetal.Incidenceandprognosisofventilator-associatedtracheobronchitis(TAVeM):a
multicentre, prospective, observational study. Lancet Respir Med. 2015
6. Martin-Loechesetal.ValidationofEuropeanCentreforDiseasePreventionandControl(ECDC)and the Centers for Disease Control and Prevention (CDC) classification of multidrug resistant organisms. J Infect. 2015
7. Martin-Loechesetal.Predictingtreatmentfailureinpatientswithcommunity-acquiredpneumonia:a case-control study. Respir Res. 2014
8. Martin-Loechesetal.Effectivenessofaninspiratorypressure-limitedapproachtomechanicalventilation
in septic patients. Eur Respir J. 2013
9. Martin-Loechesetal.ESICM/ESCMIDtaskforceonpracticalmanagementofinvasivecandidiasisin
critically ill patients. Intensive Care Med. 2019
10. Martín-Loeches et al. Variants at the promoter of the interleukin-6 gene are associated with severity and
outcome of pneumococcal community-acquired pneumonia. Intensive Care Med. 2012

I am an Intensive Care Physician working at St James's hospital. My scientific interest focuses on genetic predisposition to sepsis and pneumonia. Ultimately, my group has conducted research on respiratory sepsis-induced immunoparalysis: and compartmentalized immune response in patients with VAP.

I have active collaboration with other research groups in sepsis and pneumonia. I am currently working on transcriptomic depression of immunological synapse as a signature of ventilator-associated pneumonia analyzed by nanoliter-sized droplet technology paired with digital PCR (ddPCR).

My research questions aims always to ensure practical clinical implications.

I have established a European network and mentored PhD students to further understand the mechanisms in respiratory disease in critically ill patients.