Fellowship Call for 2019
October 12, 2018ICAT One Health Study Day Registration
February 29, 2024Full NameProfessor Richard Kennedy
CENTRE FOR CANCER RESEARCH AND CELL BIOLOGY
Queen's University Belfast
Webpage:qub.ac.uk
Email Address:Email hidden; Javascript is required.
Research Fields
- genetics, genomics and molecular biology
- cancer/oncology
- Other
Other Research Fields:
Immune checkpoint PD-L1 cGAS STING "DNA Repair"
Postgrad Medical Specialties
- Medicine
- Pathology
Medical Subspecialties
- Immunology
- Oncology
- Pharmacology
My Work
The Kennedy lab was the first to describe how genomic instability in cancer activates the cGAS-STING pathway through accumulation of cytoplasmic DNA. This results in the release of cytokines that attract lymphocytes into tumours. The cGAS-STING pathway is now known to be important in the response to novel cancer therapeutics that use the immune system to fight cancer such as PD-L1 inhibitors. The lab continue to investigate the mechanisms that activate the cGAS-STING pathway and how these can be harnessed to enhance the immune response to cancer.
Relevant publication:
https://pure.qub.ac.uk/portal/files/121087004/JNCI_J_Natl_Cancer_Inst_2017_Parkes_.pdf