Fellowship Call for 2019
October 12, 2018ICAT One Health Study Day Registration
February 29, 2024Full NameProfessor Leonie Young
Department of Surgery
Royal College of Surgeons in Ireland
Webpage:rcsi.com
Email Address:Email hidden; Javascript is required.
- cancer/oncology
- Medicine
- Surgery
Our programme of research is focused on uncovering networks involved in mediating resistance in ER-positive breast cancer, and in doing so identify markers to predict endocrine sensitivity and importantly develop new therapeutic targets.
Our approach is to focus on transcriptional networks, harnessing data from high throughput experimental methods including RNAseq, Methylseq, ChIPseq, molecular studies and translational studies. We are capitalising on our established strengths in translational research, in particular making use of cultures derived from patient tumours, PDX models and clinical datasets. This allows us to model the mechanism(s) of resistance and define new predictive markers and therapeutic targets.
- Vareslija D, McBryan J, Fagan A, Redmond AM, Hao Y, Sims AH, Turnbull A, Dixon JM, Ó Gaora P, Hudson L, Purcell S, Hill AD, Young LS. Adaptation to AI Therapy in Breast Cancer Can Induce Dynamic Alterations in ER Activity. Clin Cancer Res. 2016 1;22(11):2765-77
- McBryan J, Fagan A, McCartan D, Bane FT, VareSlija D, Cocchiglia S, Byrne C, Bolger J, McIlroy M, Hudson L, Tibbitts P, Gaora PÓ, Hill AD, Young LS. Transcriptomic Profiling of Sequential Tumors from Breast Cancer Patients Provides a Global View of Metastatic Expression Changes. Clin Cancer Res. 2015 1;21(23):5371-9.