Supervisor Database Search
Guidance for ICAT Supervisors
The ICAT Supervisor list is reviewed annually by the partner universities and updated online in March/April each year.
You can read about the ICAT supervisor selection process and eligibility criteria below:
Terms of reference/guide to supervising ICAT Fellows.
You can read the terms of reference for supervisors actively supervising ICAT Fellows below:
Supervisor Database
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Full NameProfessor Dan Longley
Patrick Johnston Centre for Cancer Research
Queen's University Belfast
Webpage:qub.ac.uk
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- cancer/oncology
- clinical trials
- Medicine
- Oncology
My research is focussed on the extrinsic apoptotic pathway regulated by death receptors. In particular, my work investigates the predictive, prognostic and therapeutic relevance of the caspase 8 inhibitor FLIP and the inhibitor of apoptosis proteins (IAPs). We have shown that FLIP and IAPs are key regulators of death receptor-, chemotherapy- and radiation-induced apoptosis in a range of in vitro and in vivo cancer models. Based on this work (accepted for publication in Mol Cancer Therapeutics), we are currently planning a phase-I clinical trial to examine the combination of a novel IAP inhibitor tolinapant (Astex Pharmaceuticals) with standard-of-care chemotherapy (FOLFOX) in metastatic colorectal cancer.