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Full NameProfessor William Gallagher
School of Biomolecular and Biomedical Science, Conway Institute
University College Dublin
Webpage:cbtlab.ie
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- genetics, genomics and molecular biology
- cancer/oncology
- clinical trials
- Medicine
- Surgery
- Pathology
- Endocrinology
- Immunology
- Oncology
The main focus of our laboratory work is to validate cancer biomarkers. Current projects include validation of OncoMasTR panel of biomarkers set in three cancer types:
a. Breast Cancer
b. Malignant Melanoma
c. Prostate Cancer
The workflow includes commercial antibody validation, staining of tissue microarray by immunohistochemistry (IHC) followed by the use of digital pathology for quantification of protein expression by IHC. Digital pathology encompasses the use of image analysis algorithms on digital images created by scanning of the glass slides. Data generated by the image analysis is then combined with patient data to identify if high/low expression of a marker is related to survival.
Suitable commercial antibodies are subjected to a very stringent validation workflow generated in our laboratory. We use commercially available CRISPR/Cas 9 gene-edited knockout cell lines, overexpression constructs, cell lines with naturally occurring high/low expression of certain proteins as a tool to ensure antibody specificity. For IHC, we use an automated platform (autostainer) for both chromogenic and fluorescence multiplexed staining. A major focus of our work is to use digital pathology and image analysis in tissue biomarker research; this task is being overseen by a dedicated histopathologist in our laboratory.