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Full NameProfessor Stephen Finn

Histopathology

Trinity College Dublin

Webpage:www.tcd.ie

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Research Fields
  • genetics, genomics and molecular biology
  • cancer/oncology
  • clinical trials
Postgrad Medical Specialties
  • Pathology
Medical Subspecialties
  • Oncology
My Work

My laboratory concentrates on two main solid tumour types, prostate and lung cancer, within which a number of established research themes exist. My group are also involved in a number of pilot studies and clinical trials in both cancer types.

Research theme 1: Identification of inflammatory based mechanisms for Circulating Tumour Cell (CTC) immune evasion in prostate cancer.
Our hypothesis is that enhanced platelet cloaking of CTCs in obese men, due to increased systemic inflammation, is a mechanism underlying worse prognosis.

Research theme 2: non-coding RNA signatures as diagnostic and prognostic tools in prostate cancer.
The use of blood and tissue based miRNA and circRNA markers for guiding clinical decision making and stratifying patients for therapy.

Research theme 3: The application of liquid biopsies as a means to identify mechanisms of drug resistance (Prostate and Lung cancer).
Detecting blood based molecular markers in cell free DNA (cfDNA) and CTCs, to further our understanding of the development of drug resistance at a genomic level using Next Generation Sequencing (NGS).

Research theme 4: Characterisation of the immune microenvironment to stratify patients for immunotherapy in lung cancer.
Validating novel techniques to accurately detect the expression of PD-1/PDL-1 in non-small cell lung cancer (NSCLC).

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