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Full NameDr Brona M Murphy

Physiology and Medical Physics

Royal College of Surgeons in Ireland

Webpage:rcsi.com

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Research Fields

genetics, genomics and molecular biology
cancer/oncology

Postgrad Medical Specialties

Medicine
Surgery
Paediatrics

Medical Subspecialties

Oncology

My Work

The broad focus of my research group is the induction of apoptotic death in glioblastoma and medulloblastoma. We develop ex-vivo and in-vivo models of these complex diseases, to examine the clinical efficacy of novel biologics, as potential treatment options for both adult and paediatric patients. I have successfully secured independent funding (~€1.2 Million) from the Health Research Board, the H2020 Research and Innovation Framework Programme and the National Children’s Research Centre to establish RCSI’s first brain tumour research group. I have mentored two post-doctoral researchers and graduated two PhD students. I am currently supervising three PhD students and a research assistant.

1. Frank Lincoln, et al., Brona M. Murphy and Markus Rehm (2018). Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism. Cell Death & Disease Nov 1;9(11):1112. doi: 10.1038/s41419-018-1160-2. [Epub ahead of print]. PMID: 30385739
2. Andreas Lindner, et al., Brona M. Murphy, William Gallagher, Arnold Hill, Leonie Young, Jochen Prehn (2018). Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers. Journal of Molecular Medicine Aug 1. doi: 10.1007/s00109-018-1675-0. [Epub ahead of print]. PMID: 30069746
3. Janis Noonan, Jennifer Zarrer, & Brona M. Murphy (2016). Targeting Autophagy in Glioblastoma. Critical Reviews in Oncogenesis 21(3-4):241-252. PMID: 27915974
4. Birgit Weyhenmeyer, Janis Noonan, et al., Markus Rehm, Brona M. Murphy (2016). Predicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozolomide. Oncotarget Sep 20;7(38):61295-61311. PMID: 27494880
5. Á. Murphy, B. Weyhenmeyer, J. Noonan, et al., B. M. Murphy (2014). Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis. Apoptosis Apr;19(4):629-42. PMID: 24213561
6. Murphy ÁC, Weyhenmeyer B, Schmid J, Kilbride SM, Rehm M, et al., Murphy BM (2013). Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach. Cell Death and Disease May 16;4:e629. PMID: 23681224