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David Williams is Professor of Stroke Medicine at the RCSI University of Medicine and Health Sciences and Consultant Stroke Physician at Beaumont Hospital Dublin. He is a fellow of the Royal Colleges of Physicians of Ireland and Edinburgh, The British Pharmacological Society, The British and Irish Hypertension Society and the European Stroke Organisation. His research interests include stroke medicine, hypertension, patient safety and prescribing. He has served as Clinical Vice-President of the British Pharmacological Society between 2007-10 and is currently managing editor of the European Journal of Clinical Pharmacology. He is currently the Irish National Speciality Director of training for Clinical Pharmacology and Therapeutics. He is the current National Director of the Irish Clinical Academic Training (ICAT) Programme and is co-director of the Irish Stroke Clinical Trials network. He was the Principal Investigator for the Irish National Adverse Events Study and Co-Lead for the HRB-funded Collaborative Doctoral Award, iPASTAR which is examining improved pathways for acute stroke care and rehabilitation.

List of Relevant Publications(Selected)

Clinical Pharmacology and Patient Safety

1. Brannigan R, et al (listed as co-author ). Potentially inappropriate prescribing and potential prescribing omissions and their association with adverse drug reaction-related hospital admissions. J Clin Med. 2024 Jan 6;13(2):323
2. Cahir C, et al (listed as co-author ).Adverse drug reactions in an ageing population (ADAPT) study: prevalence and risk factors associated with adverse drug reaction-related hospital admissions in older patients. Front Pharmacol.2023 Jan 13;13:1029067
3. Bakkum M,et al (listed as co-author). Harmonizing and improving European education in prescribing: An overview of digital educational resources used in clinical pharmacology and therapeutics. Br J Clin Pharmacol. 2021 :87(3): 1001-1011.
4. Connolly W, et al,Williams DJ. The Irish National Adverse Event Study-2(INAES-2): longitudinal trends in adverse events in the Irish Healthcare system. BMJ Qual Saf.2021 Jul;30(7):547-558 12.
5. Kennedy C, Duggan E, Bennett K, Williams DJ. Rates of reported codeine-related poisonings and codeine prescribing following new national guidance in Ireland. Pharmacoepidemiol Drug Saf. 2019 Jan; 28(1): 106-111.
6. Geoghegan SE,et al, Williams DJ. Preparedness of newly qualified doctors in Ireland for prescribing in clinical practice. Br J Clin Pharmacol. 2017 Aug 83(8):1826-34
7. Rafter N, et al, Williams DJ. The Irish National Adverse Events Study (INAES): the frequency and nature of adverse events in Irish hospitals-a retrospective record review study. BMJ Qual Saf. 2017 Feb;26(2):111-119
8. Byrne C, Walsh C, Cahir C, Ryan C, Williams DJ, Bennett K. Anticholinergic and sedative drug burden in community-dwelling older people: a national database study. BMJ Open 2018 Jul 6;8(7):e022500;8
9. Williams D. The great ESCAPE-a clinical pharmacologist’s journey in stroke research. Br J Clin Pharmacol. 2016, Aug; 82(2):334-9.
10. Williams D. Monitoring medicines use: The Role of the Clinical Pharmacologist. Br J Clin Pharmacol. 2012: 74;685-90
11. McGreevy C, Williams D. Safety of drugs used in the treatment of osteoporosis. Therapeutic Advances in Drug Safety. Aug 2011:2(4);159-172
12. McGreevy C, Williams D. New insights about vitamin D and Cardiovascular disease. Annals of Internal Medicine, 2011;115. 820-826
13. Williams D, Singh M, Hind C. The effect of the withdrawal of rofecoxib on prescribing patterns of COX-2 inhibitors in Scotland. Br J Clin Pharmacol. 2006 Sep; 62 (3): 366-68.
14. Williams D. Bennett K, Feely J. The application of Prescribing Indicators to a primary care prescription database in Ireland. Eur J Clin Pharmacol 2005 Apr;61(2):127-134
15. Williams D, Bennett K, Feely, J. Prescribing for osteoporosis following the use of inhaled and oral corticosteroids in general practice. Br J Clin Pharmacol 2004 Dec; 58(6) 665-72
16. Williams D. et al,Feely J. Influence of material deprivation on prescribing patterns within the deprived population. Eur J Clin Pharmacol 2003 Oct; 59(7): 559-563
17. Williams D. Bennett K, Feely, J. Evidence for an age and gender bias in the secondary prevention of ischaemic heart disease in primary care. Br J Clin Pharmacol 2003 Jun;55(6):604-8
18. Williams D, Feely J. Pharmacokinetic/Pharmacodynamic Drug interactions with HMG-CoA Reductase inhibitors. Clinical Pharmacokinetics. 2002; 41(5): 343-370.
19. Williams D, Kelly A, Feely, J. Preferential prescribing of oral corticosteroids to male asthmatic children Br J Clin Pharmacol 2001 Sep;52(3):319-21 PMID:11560565
20. Williams D, Kelly, A, Feely, J. Drug interactions avoided – a useful indicator of good prescribing practice Br J Clin Pharmacol 2000 Apr;49(4):369-72

Stroke and Vascular Medicine

21. Kelly P, et al (listed as co-author ). Long-term colchicine for the prevention of vascular recurrent events in non-cardioembolic stroke (CONVINCE): a randomized controlled trial. Lancet https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00968-1/fulltext
22. Coutts SB,et al (listed as co-author).Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion(TEMPO-2): a randomized, open label, phase 3 superiority trial. Lancet https://doi.org/10.1016/S0140-6736(24)00921-8 May 2024
23. Soo Y, Zietz A, et al (listed as co-author) on behalf of the Microbleeds International Collaborative Network . Impact of Cerebral Microbleeds in Stroke Patients with Atrial Fibrillation. Ann Neurol. 2023 Jul;94(1):61-74.
24. Best JG,et al(listed as co-author) Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke or transient ischaemic attack:a pooled analysis of individual patient data from cohort studies.Lancet Neurol. 2021 Apr;20(4): 294-303.
25. Bejleri J, Jirstrom E, Donovan P, Williams DJ, Pfeiffer S. Diagnostic and Prognostic Circulating MicroRNA in Acute Stroke: A Systematic and Bioinformatic Analysis of Current Evidence. J Stroke.2021 May;23(2):162-182.
26. Joundi RA,et al(listed as co-author).Health-Related Quality of Life Among Patients With Acute Ischaemic Stroke and Large Vessel Occlusion in the ESCAPE Trial. Stroke. 2021,Mar 11. PMID: 33691504
27. Byrne C, et al, Williams DJ. Short-term Air Pollution as a Risk for Stroke Admission: A Time Series Analysis. Cerebrovasc Dis 2020;49(4): 404-411
28. Kelly PJ,et al, (listed as co-author) A Risk score including carotid plaque inflammation and stenosis severity improves identification of recurrent stroke. Stroke 2020 Mar;51(3):838-845
29. Holodinsky JK et al, Williams D. Drip and Ship versus direct to endovascular thrombectomy: The impact of treatment times on transport decision-making. Eur Stroke J. 2018 Jun;3(2): 126-135.
30. Gaynor E, et al, Williams D. Cognitive Impairment, Vulnerability, and Mortality Post Ischaemic Stroke: A Five-Year Follow-Up of the Action on Secondary Prevention Interventions and rehabilitation in Stroke (ASPIRE-S) Cohort. J Stroke Cerebrovasc Dis.2018 Sep;27(9):2466-2473.
31. Wilson D, et al (listed as co-author).Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Lancet Neurol. 2019 Jul;18(7):653-665.
32. Menon, B, et al (listed as co-author) Analysis of Workflow and Time to treatment on Thrombectomy Outcome in the ESCAPE Randomised Controlled Trial. Circulation 2016;133:2279-86 PMID: 27076599
33. Goyal M,et al (listed as co-author)Randomised Assessment of Rapid Endovascular Treatment of Ischaemic Stroke. N Engl J Med 2015;372:1019-1030.
34. Brewer L,et al, Williams D. Secondary prevention after ischaemic stroke: the ASPIRE-S study. BMJ Neurology. 2015 Oct 23;15:216.
35. McCreevy C, et al,Williams D. The effect of vitamin D supplementation on arterial stiffness in an elderly community-based population. J Am Soc Hypertens. 2015 9(3) 176-183
36. Simpson C,et al, Williams D. The effect of the UK incentive-based contract on the management of patients with stroke in primary care. Stroke 2006 Sep;37(9):2354-60
37. Simpson C,et al Williams D. Evidence for age and sex differences in the secondary prevention of stroke in Scottish primary care. Stroke. 2005 Aug; 36(8):1771-5
38. Simpson C,et al,Williams D. Evidence for Inequalities in the Management of Coronary Heart Disease in Scotland. Heart 2005 May 91:5;630-4