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Full NameProfessor Kingston Mills
Biochemistry and Immunology
Trinity College Dublin
Webpage:www.tcd.ie
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- infectious disease and the immune system
- Medicine
- Paediatrics
- Infectious diseases
- Immunology
My group was the first to define a role for cellular immunity in protection against Bordetella pertussis. We defined protective roles for Th1 cells and subversive roles for Treg cells, published in J. Exp Med, and J. Immunol, and Nature Reviews Immunology. We provided the first definitive evidence that cellular immunity mediated by Th1 cells and Th17 plays a critical role natural immunity to B. pertussis. We demonstrated that infection of children with B. pertussis induced antigen-specific Th1 cells. We were also the first to describe pathogen-specific regulatory T cells in infection and that these cells constrain protective immunity to B. pertussis. More recently we have identified a role for lung tissue resident memory T cells in sustaining immunity to B. pertussis
Our work in autoimmune diseases demonstrated a key role for TLR-induced IL-1 and IL-23 in IL-17 production by T cells and a key pathogenic role for gamma-delta T cells. Our J. Exp Med article showed that IL-1 plays an essential role in IL-17 production by Th17 cells that are pathogenic in autoimmune diseases. Our Immunity paper provided the first evidence that γδ T cells play a pathogenic role in autoimmune disease through IL-17 production driven by innate cytokines.