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Full NameProfessor Richard Kennedy

Patrick G Johnston Centre for Cancer Research

Queen's University Belfast

Webpage:qub.ac.uk

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Research Fields

genetics, genomics and molecular biology
cancer/oncology
Other

Other Research Fields:

Immune checkpoint PD-L1 cGAS STING "DNA Repair"

Postgrad Medical Specialties

Medicine
Pathology

Medical Subspecialties

Immunology
Oncology
Pharmacology

My Work

The Kennedy lab was the first to describe how genomic instability in cancer activates the cGAS-STING pathway through accumulation of cytoplasmic DNA. This results in the release of cytokines that attract lymphocytes into tumours. The cGAS-STING pathway is now known to be important in the response to novel cancer therapeutics that use the immune system to fight cancer such as PD-L1 inhibitors. The lab continue to investigate the mechanisms that activate the cGAS-STING pathway and how these can be harnessed to enhance the immune response to cancer.

Relevant publication:
https://pure.qub.ac.uk/portal/files/121087004/JNCI_J_Natl_Cancer_Inst_2017_Parkes_.pdf