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Full NameProfessor Aoife Lowery

Surgery

University of Galway

Webpage:nuigalway.ie

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Research Fields

genetics, genomics and molecular biology
cell and developmental biology/regenerative medicine
cancer/oncology

Postgrad Medical Specialties

Surgery

Medical Subspecialties

Endocrinology
Oncology

My Work

The work undertaken by this research group, is translational research focused on improving diagnosis, treatment and outcomes for cancer patients. There are two predominant themes:

1. Evaluation of novel imaging and biomarkers for detection and prognostication in early breast cancer. This work focuses on identification of miRNA biomarkers which have the potential to stratify early breast cancer according to disease type and response to therapy. We propose that combining information relating to the molecular properties of tumours and image phenotype information, with clinical data will more accurately predict treatment response or prognosticate. Ultimately this approach will aim to facilitate better selection of breast cancer patients for individualized therapy

2. Development of innovative approaches to post-surgical reconstruction for breast cancer patients. This is an interdisciplinary approach utilising recent advances in regenerative medicine, biomaterials and clinical sciences to develop alternative cell-based approaches to breast reconstruction, the oncological safety of which will be assessed in pre-clinical models, which will be fundamental for successful clinical translation. This work is performed in collaboration with Professor Garry Duffy (http://www.curamdevices.ie/curam/about-us/our-people/investigators/professor-garry-duffy-.html) and collaborators in Surgery and Regenerative Medicine.

Hydrogels in adipose tissue engineering-Potential application in post-mastectomy breast regeneration. O'Halloran NA, Dolan EB, Kerin MJ, Lowery AJ, Duffy GP.
J Tissue Eng Regen Med. 2018 Dec;12(12):2234-2247.PMID: 30334613

Adipose-Derived Stem Cells in Novel Approaches to Breast Reconstruction: Their Suitability for Tissue Engineering and Oncological Safety. O'Halloran N, Courtney D, Kerin MJ, Lowery AJ. Breast Cancer (Auckl). 2017. PMID: 29104428

Role of micro-RNAs in breast cancer surgery. McAnena P, Lowery A, Kerin MJ.
Br J Surg. 2018 Jan;105(2):e19-e30. doi: 10.1002/bjs.10790.PMID: 29341144