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Full NameProfessor Matthew Griffin
- infectious disease and the immune system
- cell and developmental biology/regenerative medicine
- clinical trials
- Medicine
- Surgery
- Pathology
- Endocrinology
- Gastroenterology
- Haematology
- Infectious diseases
- Immunology
- Nephrology
- Pharmacology
- Rheumatology
- Vascular Medicine
My research has focussed for the past 20 years on basic and translational studies of the immune system and inflammation - particularly their contributions to the pathophysiology of kidney disease and transplantation (e.g. Kidney Int. 2007,71:619-628; J Am Soc Nephrol, 21: 1987-1997,2010; J Am Soc Nephrol, 23:194-203,2012). Since returning to Ireland in 2008, I have directed these interests to the field of regenerative medicine and allogeneic cell therapies with an emphasis on the immunomodulatory properties of mesenchymal stromal cells/MSC (e.g. Am J Physiol Renal Physiol 307:F1412-26,2016; Stem Cells, 31:2033-41,2014; Immunol Cell Biol, 96: 536–548,2018; Frontiers Immunol, Nov 20;9:2666,2018).
With colleagues and collaborators in REMEDI and at several leading centres in Europe and the US, my group has recently been closely involved in translating allogeneic cell therapies to the clinic through regulator-approved early phase clinical trials (see www.visicort.eu and www.nephstrom.eu) as well as biomarker and immune profiling studies (e.g. Immunol Cell Biol, 96: 675-784,2018; Frontiers Immunol, Dec 6;9:2845,2018; Clin Chem Lab Med, ePub, Sept 15,2018). We have strong expertise in flow cytometry, primary immune cell isolation and culture, immunoassays, pre-clinical models and histology/immunohistochemistry. We also have extensive experience in patient-oriented research.