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Full NameDr Michael Conall Dennedy
Discipline of Pharmacology & Therapeutics
University of Galway
Webpage:nuigalway.ie
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- cell and developmental biology/regenerative medicine
- cancer/oncology
- bioengineering/medical devices
- Medicine
- Surgery
- Pathology
- Radiology
- Cardiology
- Endocrinology
- Nephrology
- Oncology
- Pharmacology
- Vascular Medicine
The focus of our laboratory group is on imaging and therapeutics of functioning adrenocortical tumours. Our research is translational cell biology which is linked to the adrenal and hypertension clinical services. More broadly, we currently look at two therapeutic areas:
1. Thermal therapy of Functioning Adrenocortical Tumours - (Associated Clinical Services: Hypertension and Adrenal Clinics)
We lead a cross-institutional group (Kansas State University, University of Cambridge, Mayo Clinic Rochester) and take a multi-disciplinary approach across medicine, physics, engineering and radiology, to explore thermal therapeutics of benign and malignant adrenocortical tumours looking at (i) microwave ablation, (ii) nanotechnology, (iii) thermally-sensitive liposomes and (iv) extra-cellular vesicles.
2. Lipotoxicity in Adrenocortical Cancer - (Associated Clinical Services: Adrenal Clinic)
This work investigates the role of nuclear receptors in adrencortical cancer and how modulation of LXR can induce lipotoxicity in these cancer cells by affecting lipid-droplet integrity and steroidogenesis.