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Full NameProfessor Isabel Rozas
School of Chemistry
Trinity College Dublin
Webpage:chemistry.tcd.ie
Email Address:Email hidden; Javascript is required.
- cancer/oncology
- neuroscience and mental health
- clinical trials
- Other
Drug discovery and medicinal chemistry
- Medicine
- Neuropsychiatry
- Oncology
- Pharmacology
The design, synthesis, biophysical and biochemical study of:
(i) dual action agents targeting DNA as intercalators and minor-groove binders with potential as more selective anticancer drugs (SFI). P.S. Nagle, C. McKeever, F. Rodriguez, B. Nguyen, W.D. Wilson, I. Rozas. J. Med. Chem. 7663-7672, 57 (2014)
(ii) chemical probes targeting Guanine-Quadruplexes in oncogenic precursors of Ras, B-Raf, or c-Myc. I. Rozas, M.O. Senge. Future Med. Chem. 609-612, 8 (2016)
(iii) Pt complexes of guanidinium based DNA minor-groove binders with potential as anticancer drugs (SFI). M. Marin-Luna, G. Sanchez-Sanz, P. O?Sullivan, I. Rozas. J. Phys. Chem. A 5540-5547, 118 (2014)
The design, synthesis and biochemical study of guanidinium derivatives as tyrosine or threonine/serine kinase inhibitors as anticancer activity (School of Chemistry -TCD-, Ulysses award). E. Diez-Cecilia, B. Kelly, C. Perez, D.M. Zisterer, D.K. Nevin, D.G. Lloyd, I. Rozas. Eur. J. Med. Chem. 427-441, 81 (2014).
The design, synthesis and pharmacological study of antagonists of alpha2- or alpha2C-adrenoceptors as antidepressants or antipsychotics (IRC). (a) M. McMullan, A. Garcia-Bea, P. Miranda-Azpiazu, L.F. Callado, I. Rozas. Eur. J. Med. Chem. 48-57, 123 (2016). (b) B. Kelly, M. McMullan, C. Muguruza, J.E. Ortega, J.J. Meana, L.F. Callado I. Rozas. J. Med. Chem. 963-977, 58 (2015)