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Full NameProfessor Orla Sheils
Histopathology
Trinity College Dublin
Webpage:people.tcd.ie
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- cancer/oncology
- Pathology
The underlying theme of my research is to understand the causes and molecular basis of the development of disease, with particular reference to cancer and metastasis of solid tumours, and to apply this knowledge to improving disease prevention, detection, diagnosis, and treatment.
I have a particular interest in developing novel molecular diagnostics. Translational patient centered research is the common theme throughout my research, linking identification of disease processes with targets for early disease detection or classification.
Ongoing research is examining the pivotal role of co-morbidities in Non Communicable Diseases. We are specifically working to identify synergistic effects of disparate patho-biology, including host immune system and metabolism, lifestyle, and environmental factors linking prognosis with multi-morbidities or indeed resilience to disease.
Other specific areas of research include:
- understanding the interaction between environment/exposome and genes/their expression.
- identifying and isolating biologically relevant Circulating Tumour Cells
- identifying rare mutations among Cell Free DNA samples
- understanding the interplay between platelets and coagulation system with regard to enablement of metastasis
- Identifying mechanisms of immune evasion in metastasis