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Full NameProfessor Padraic Fallon
Clinical Medicine
Trinity College Dublin
Webpage:medicine.tcd.ie
Email Address:Email hidden; Javascript is required.
- infectious disease and the immune system
- Medicine
- Pathology
- Dermatology
- Gastroenterology
- Immunology
- Respiratory Medicine
Research in Fallon group involves two overlapping translational immunology themes:
i. The use of mouse models, transgenic and mutant strains, to study basic mechanisms of inflammatory diseases and helminth immunity.
ii. Immune phenotyping of patients with inflammatory diseases, such as atopic dermatitis and pulmonary fibrosis.
Research aims to elucidate new mechanism of modulation of immunity that can alter inflammatory processors and have therapeutic potential. The main diseases addressed are fibrotic disorders, allergic lung and skin inflammation and inflammatory bowel disease.
Research in the Fallon group has made fundamental mechanistic translational research discoveries, selected examples from 2016 publications:
Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase.
Jarrett et al. Sci Transl Med. 2016 8:325ra18.
Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity.
Saunders et al. Allergy Clin Immunol. 2016 137:482-91.
The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism.
Hams E et al. FASEB J. 2016 30:824-35.
Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses.
Halim et al. Nature Immunology. 2016 17:57-64.