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Full NameProfessor Ronan Cahill
School of Medicine
University College Dublin
Webpage:www.ucd.ie
Email Address:Email hidden; Javascript is required.
- physiology and non-communicable disease
- cancer/oncology
- Other
Fluorescence, laparosopy, surgery
- Surgery
- Sports and Exercise Medicine
- Gastroenterology
Health and disease as well as recovery from surgery and disease requires dynamic interplay between the immune system and perfusion. Surgery is a visualisation specialty that is moving to individualize its strategy around the patient in addition to the disease. Fluorescence surgery already allows improved care with non-selective fluorophores and this will certainly advance in the near future with the evolution and translation of novel selective agents targeted to both disease and tissue microenvironment.
Our focussed next step-advances will relate to smart labelled colorectal endoscopic tattoo and lymph node identification as well as vascular perfusion of gastrointestinal pathology and anastomosis both at the time of their construction and sequentially postoperatively as the patient recovers from surgery as well as any peroperative complications.
One project with Prof O'Shea's group involves bench, biomedical and clinical development of specific near infrared fluorophore probes for dynamic tissues assessment (ischemia as well as malignancy relates effects and anatomy). Related work will include response to preoperative preparatory exercise effort especially in the colonic environment including normal as well as abnormal tissue and cellular interaction before and after main vessel division and specifically also in the perioperative phase in patients undergoing supervised aerobic and anaerobic preoperative exercise. Additional work includes clinical trial translation of concepts such as natural orifice endoscopic surgery, transanal total mesorectal excision, multiquadrant robotic working and the microbiome.
This project offers both laboratory and clinical research involving the generation of bio-conjugated novel NIR-fluorophores which target specific cancer cell markers, their assessment in cellular assays and determination of their cancer selective imaging potential using state of the art clinical instrumentation. The specific clinical goals are focused on imaging of colorectal cancer and the response of host tissue and immune system to surgery.