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Full NameProfessor Stephen Pennington
School of Medicine
University College Dublin
Webpage:www.ucd.ie
Email Address:Email hidden; Javascript is required.
- genetics, genomics and molecular biology
- cell and developmental biology/regenerative medicine
- physiology and non-communicable disease
- cancer/oncology
- clinical trials
- Medicine
- Surgery
- General Practice
- Pathology
- Public Health
- Cardiology
- Community Medicine
- Geriatric Medicine
- Health Informatics
- Immunology
- Oncology
- Pharmacology
- Physiology
- Rheumatology
We are engaged in the application of the latest developments in proteomics strategies to the elucidation of disease mechanisms and identification of disease markers to make significant advances in personalised medicine by identifying and developing protein biomarkers to support patient stratification.
We are currently active in two major disease areas:
i) prostate cancer (see: Tonry C et al. The Role of Proteomics in Biomarker Development for Improved Patient Diagnosis and Clinical Decision Making in Prostate Cancer. Diagnostics. 2016, 6: 27; Staunton L et al, Profiling the tumor microenvironment proteome in prostate cancer using laser capture microdissection coupled to LC-MS EuPA Open Proteomics. 2016, 10:19-23.; Tonry CL, et al. Discovery and Longitudinal Evaluation of Candidate Protein Biomarkers for Disease Recurrence in Prostate Cancer. J Proteome Res. 2015, 14:2769-83)
ii) inflammatory arthritis (see: McArdle et al. Developing Clinically Relevant Biomarkers in Inflammatory Arthritis: A Multi-Platform Approach for Serum Candidate Protein Discovery. Proteomics Clin Appl. 2015 doi: 10.1002/prca.201500046; Mc Ardle A et al.. Early biomarkers of joint damage in rheumatoid and psoriatic arthritis. Arthritis Res Ther. 2015, 17:141. Ademowo OS, et al. Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis. Ann Rheum Dis. 2014 doi: 10.1136/annrheumdis-2014-205417.)
We are particularly interested in translating our lab-based research findings to clinical utility (see: Hernandez B, Pennington SR, Parnell AC. Bayesian methods for proteomic biomarker development. EuPA Open Proteomics. 2015, 9:54-64; Percy et al.. Clinical Translation of MS-based Quantitative Plasma Proteomics: Status, Challenges, Requirements, and Potential. Expert Rev Proteomics. doi: 10.1080/14789450.2016.1205950) and have recently founded a small company - Atturos - to support this endeavour (www.atturos.com).