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Full NameProfessor Laurence Egan
National University of Ireland Galway
Webpage:nuigalway.ie
Email Address:Email hidden; Javascript is required.
- infectious disease and the immune system
- cell and developmental biology/regenerative medicine
- physiology and non-communicable disease
- cancer/oncology
- bioengineering/medical devices
- Medicine
- Gastroenterology
- Pharmacology
The research group of Professor Egan is focussed on optimising treatment approaches for individual patients with inflammatory bowel diseases. We also have an interest in understanding better some of the complications of inflammatory bowel disease, most notably the development of colon cancer. Some of our key discoveries in the past include elucidation of the key role of the transcription factor NFκB in the pathophysiology of colitis and colitis associated colon cancer, radiation enteritis and colon cancer metastasis.
Other work has focused on developing a better understanding of the mechanisms of resistance to treatment with anti-TNF monoclonal antibodies such as infliximab. Our most recent results indicate that infliximab exerts profound effects on circulating blood monocytes. Current work is investigating whether the effect of infliximab on this key pro-inflammatory cell type is a particular of treatment resistance versus response in inflammatory bowel disease patients.