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Full NameDr Mark Robinson
Department of Immunology
Trinity College Dublin
Webpage:www.tcd.ie
Email Address:Email hidden; Javascript is required.
- infectious disease and the immune system
- Medicine
- Surgery
- Pathology
- Gastroenterology
- Infectious diseases
- Immunology
Liver cirrhosis accounts for 170,000 deaths per year in Europe, and once refractory complications arise in patients with cirrhosis, liver transplantation is currently the sole treatment option available. Utilising diseased liver tissue obtained during transplantation, peripheral blood samples, and liver biopsy sections, we are defining the changes in tissue-resident immune cells in disease. These data will inform the development of 3D hepatocyte cell culture systems to study the interactions of hepatocytes with resident immune cells, and the roles these interactions play in liver pathology. Finally, novel inflammatory biomarkers will be identified and tested in patients living with stable cirrhosis who are at risk of disease progression. This research into the clinical impact of dysfunction or loss of tissue-resident immune cell populations will shed new insights into liver cirrhosis and liver immunology. This will open up new avenues in our approach to the clinical management of liver cirrhosis, providing more options to patients living with chronic liver disease.
More information: https://www.tcd.ie/ttmi/