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Full NameProfessor Paul McLoughlin
Conway Institute
University College Dublin
Webpage:people.ucd.ie
Email Address:Email hidden; Javascript is required.
- physiology and non-communicable disease
- bioengineering/medical devices
- Medicine
- Surgery
- Anaesthetics
- Paediatrics
- Pathology
- Cardiology
- Physiology
- Respiratory Medicine
- Vascular Medicine
Our research explores key mechanisms in the development and progression of chronic hypoxic lung diseases characterized by inflammation and pulmonary fibrosis.
We have shown that a specific family of proteins, known as the bone morphogenetic antagonists, plays a major role in the development of hypoxic pulmonary hypertension (WHO Group 3 PH) and more recently we have shown that these proteins also contribute to the development of idiopathic pulmonary fibrosis (1-3). We are currently exploring the molecular pathways through which one of the most important members of this family (gremlin 1) acts (4).
A second research focus is altered endothelial barrier function and the development of pulmonary oedema in diseases such as ARDS and systemic sepsis. Interestingly, this work also has the potential to improve the supply of donor lungs for transplant by enhancing ex vivo machine perfusion strategies (5).
1. Cahill et al. Circulation. 2012 Feb 21;125(7):920-30. PMID: 22247494
2. Murphy et al. Am J Pathol. 2016 Mar;186(3):600-15. PMID: 26765958
3. Rowan et al. Lancet Respir Med. 2016 Mar;4(3):225-36. PMID: 26895650
4. Rowan et al. Pulm Circ. 2018 Oct 4:2045894018807205. doi: 10.1177/2045894018807205. PMID: 30284507
5. Rowan et al. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L476-L484. PMID: 29792349