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Full NameProfessor Declan McLoughlin

Medicine

Trinity College Dublin

Webpage:www.tcd.ie

Email Address:Email hidden; Javascript is required.

Research Fields

genetics, genomics and molecular biology
neuroscience and mental health
clinical trials

Postgrad Medical Specialties

Psychiatry
Public Health

Medical Subspecialties

Neuropsychiatry
Pharmacology

My Work

Depression is a common debilitating mental illness afflicting 12% of people during their lifetime. At worst, it is life-threatening due to severe self-neglect and up to 6% will die by suicide. According to the WHO, depression is now the leading cause of disability worldwide. The Depression Neurobiology Research Group is a multidisciplinary team of clinicians, research fellows, and postgraduate students. Our research encompasses clinical assessment, neuropsychology, randomised controlled trials, meta-analysis, and molecular biology methods.

RECENT PUBLICATIONS
Ryan KM, Dunne R, McLoughlin DM (2018) BDNF plasma levels and genotype in depression and the response to electroconvulsive therapy. Brain Stimul 11(5):1123-1131.

Kolshus E, Ryan KM, Blackshields G, Smyth P, Sheils O, McLoughlin DM (2017) Peripheral blood microRNA and VEGFA mRNA changes following electroconvulsive therapy: implications for depressive psychosis. Acta Psych Scand 136(6):594-606.

Kolshus E, Jelovac A, McLoughlinDM (2017) Bitemporal versus high-dose right unilateral electroconvulsive therapy for depression: a systematic review and meta-analysis of randomised controlled trials. Psychol Med 47 (3):518-530.

Semkovska M, Landau S, Dunne R, Kolshus E, Kavanagh A, Jelovac A, Noone M, Carton M, Lambe S, McHugh C, McLoughlin DM (2016) Bitemporal versus high-dose unilateral twice-weekly electroconvulsive therapy for depression (EFFECT-Dep): a pragmatic, randomised, non-inferiority trial. Am J Psychiatry 173(4):408-17.