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Full NameDr Cian O'Leary

School of Pharmacy and Biomolecular Sciences

Royal College of Surgeons in Ireland

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Research Fields
  • cell and developmental biology/regenerative medicine
  • physiology and non-communicable disease
  • cancer/oncology
  • bioengineering/medical devices
Postgrad Medical Specialties
  • Medicine
Medical Subspecialties
  • Oncology
  • Otorhinolaryngology
  • Pharmacology
  • Physiology
  • Respiratory Medicine
My Work

The O'Leary Lab is focused on discovering and developing new treatments for chronic diseases with cell-matrix dysregulation at the centre of their pathogenesis. To this end, Dr O'Leary's lab focuses on developing novel disease models of 3D cell environments that mimic diseased tissue in the body in order to identify unexplored, druggable targets for which medicinal products can be designed and formulated to strategically strike these targets for the ultimate aim of improving clinical outcomes in chronic disease.

Major research themes include:
- Mechanopharmacology: Understanding mechanobiology in disease to develop pharmacological agents that target cell-matrix interactions.
- Tissue engineered 3D in vitro models of epithelial interfaces and biological barriers.
- Drug formulation of new treatments to prevent or reverse fibrosis.
- Drug repurposing through novel formulation development.
- Respiratory tissue regeneration and medical device development.

Chronic conditions of interest include:
- Lung cancer (NSCLC).
- Pancreatic cancer (PDAC).
- Idiopathic pulmonary fibrosis and interstitial lung disease.
- Cystic fibrosis.

For a full list of publications, please visit Dr O'Leary's Google Scholar profile at