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Full NameProfessor Kumlesh Dev

Dept of Physiology

Trinity College Dublin

Webpage:www.tcd.ie

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Research Fields
  • genetics, genomics and molecular biology
  • neuroscience and mental health
  • Other
Other Research Fields:

Neurology, Psychiatry, Immune system

Postgrad Medical Specialties
  • Psychiatry
  • Paediatrics
Medical Subspecialties
  • Child and Adolescent Psychiatry
  • Immunology
  • Neurology
  • Neurophysiology
  • Neuropsychiatry
  • Pharmacology
  • Physiology
My Work

Our research lies within the area of Neuroscience, with an interest in drug development and biomarker studies for neurological and psychiatric illnesses. We focus primarily on investigating the biology of glial cells, specifically the analysis of astrocyte-derived biomarkers. These cells play a role in a number of psychiatric, neurodegenerative and neurological diseases, making their study of importance to aid our understanding of normal and abnormal brain function. Disorders such as schizophrenia appear to have both genetic and environmental triggers, which interplay in a complex and not as yet fully understood manner.

Over the past 5-6 years, we have been analysing the levels of cytokines and chemokines in plasma and serum samples of patients with schizophrenia and find these molecules may be altered. One of the projects available in our group will aim to further these studies.

Relevant References:
O'Connell et al (2015) Increased IL23 in schizophrenia. Cytokine 73,196-198.
O'Connell & Dev (2014) Immune and Metabolic Factors of Schizophrenia. J Psych Behav Sci 1, 005.
O'Connell et al (2014) Premium of a big pharma license deal. Nature Biotechnology 32, 617-619.
O'Connell et al (2014) Cytokine signature patterns in Multiple Sclerosis. Autoimmunity 30, 1-7.
O'Connell et al (2014) Cytokine levels in schizophrenia. Schizophrenia Research 156, 1-8.
O'Connell et al (2013). S100B levels in schizophrenia BMC Psychiatry 13,146.

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