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Full NameDr Ignacio Martin-Loeches
Department:Critical Care Medicine
Organisation:Trinity College Dublin
- genetics, genomics and molecular biology
- infectious disease and the immune system
- epidemiology/population health research
- Emergency Medicine
- Clinical Trials
- Health Informatics
- Infectious diseases
- Respiratory Medicine
My group has an special focus on the interdisciplinary research group focusing on clinical and translational research in critical illness
Major research domains include:
Sepsis and acute lung injury
Organ dysfunction, support, and recovery
Translational medicine in critical care
Precision medicine and predictive analytics
Severe infections in critical care
1.Martin-LoechesIetal.Increasedincidenceofco-infectionincriticallyillpatientswithinfluenza.Intensive Care Med. 2017
pneumonia: the interaction of ecology, shock and risk factors. Intensive Care Med. 2013
3. Martin-Loechesetal.UseofearlycorticosteroidtherapyonICUadmissioninpatientsaffectedby severe pandemic (H1N1)v influenza A infection. Intensive Care Med 2010.
mortality is restricted to patients with moderate organ failure. Ann Intensive Care. 2017
multicentre, prospective, observational study. Lancet Respir Med. 2015
6. Martin-Loechesetal.ValidationofEuropeanCentreforDiseasePreventionandControl(ECDC)and the Centers for Disease Control and Prevention (CDC) classification of multidrug resistant organisms. J Infect. 2015
7. Martin-Loechesetal.Predictingtreatmentfailureinpatientswithcommunity-acquiredpneumonia:a case-control study. Respir Res. 2014
in septic patients. Eur Respir J. 2013
critically ill patients. Intensive Care Med. 2019
10. Martín-Loeches et al. Variants at the promoter of the interleukin-6 gene are associated with severity and
outcome of pneumococcal community-acquired pneumonia. Intensive Care Med. 2012
I am an Intensive Care Physician working at St James's hospital. My scientific interest focuses on genetic predisposition to sepsis and pneumonia. Ultimately, my group has conducted research on respiratory sepsis-induced immunoparalysis: and compartmentalized immune response in patients with VAP.
I have active collaboration with other research groups in sepsis and pneumonia. I am currently working on transcriptomic depression of immunological synapse as a signature of ventilator-associated pneumonia analyzed by nanoliter-sized droplet technology paired with digital PCR (ddPCR).
My research questions aims always to ensure practical clinical implications.
I have established a European network and mentored PhD students to further understand the mechanisms in respiratory disease in critically ill patients.