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Full NameProfessor Alistair Nichol

Department:Dept of Critical Care Medicine

Organisation:University College Dublin

Email Address:Email hidden; Javascript is required.

Research Fields
  • epidemiology/population health research
Postgrad Medical Specialties
  • Medicine
  • Anaesthetics
  • Emergency Medicine
  • Public Health
Medical Subspecialties
  • Clinical Trials
My Work

The Irish Critical Care Trials Group was established by a group of clinician researchers back in 2007.

In 2010 we commenced out first interventional randomised controlled trial of a statin in 534 patients with Acute Respiratory Distress Syndrome (NEJM, October 2014, see CTG publications).

Since then the ICC-CTG, completed a demographic study of the burden of critical care in Ireland in 2014, to determine feasibility for future interventional studies (in preparation) and established a point prevalence program (see research).

The ICC-CTG members have taken part in two international interventional randomised controlled trials coordinated by the Australian and New Zealand Intensive Care Research Centre, Melbourne, Australia. These were published in the NEJM in 2014 (ARISE) and the Lancet in 2015 (EPO-TBI), see publications.

Furthermore, the CTG is currently engaged in 4 large randomized controlled trials (see current research) in collaboration with Canada, Australia and New Zealand and the United Kingdom.

These efforts to date demonstrate that key support is a team of highly motivated ICU clinicians who are committed to the IC- CTG and who work in all the major ICUs in Ireland and who in combination provide care to the overwhelming majority of critically ill patients in the Island of Ireland.

Potential Projects



The PHARLAP-RCT is a prospective, multi-centre, randomised controlled trial of the clinical efficacy of a ventilation strategy (called PHARLAP) compared to standard mechanical ventilation in acute respiratory distress syndrome (ARDS). This trial will be collaboration between Intensive Care Units of the Irish Critical Care- Clinical Trails Group (ICC- CTG) and the Australian and New Zealand Intensive Care Society- Clinical Trials Group (ANZICS-CTG).


TRANSFUSE-RCT is a multi-centre, randomised, controlled trial, testing the effect of the freshest available red blood cell (RBC) unit compared to standard practice, on mortality in critically ill patients who require RBC transfusion.

The results have recently been presented at ESICM2017 in Vienna and published in the New England Journal of Medicine.


SPICE III is a prospective, un-blinded, randomised controlled trial of Early Goal-Directed Sedation (EGDS) compared with standard care. The study will recruit patients who are intubated and ventilated in a participating ICU, are expected to remain intubated the day after enrolment and need immediate and ongoing sedation.