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Full NameProfessor Catherine Godson
Diabetes Complications Research Centre, Conway Institute and School of Medicine
University College Dublin
Webpage:www.ucd.ie
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- genetics, genomics and molecular biology
- infectious disease and the immune system
- cell and developmental biology/regenerative medicine
- physiology and non-communicable disease
- Other
Inflammation and immunity
- Medicine
- Surgery
- Anaesthetics
- Ophthalmology
- Paediatrics
- Pathology
- Public Health
- Adolescent medicine
- Cardiology
- Cardiac Surgery
- Dermatology
- Endocrinology
- Gastroenterology
- Geriatric Medicine
- Health Informatics
- Infectious diseases
- Immunology
- Nephrology
- Pharmacology
- Respiratory Medicine
- Rheumatology
- Vascular Medicine
Work in my group focuses on the molecular mechanisms underlying the initiation, progression and potential regression of microvascular complications of diabetes. We have a particular interest in the resolution of inflammation and how this may be subverted in numerous prevalent diseases. We have identified a role for endogenously generated lipid mediators [lipoxins, LXs] in promoting the resolution of inflammation. Working in collaboration with Prof. Pat Guiry's group in Chemistry, UCD we have generated a series of novel synthetic mimetics of LX bioactions. We are currently characterising the bioactions of these molecules in in vitro and in vivo model systems and human tissue ex vivo. Our findings indicate potent, specific responses to these proprietary agents in the context of unresolved inflammation including atherosclerosis, CKD,sepsis and arthritis.
We are part of an international consortium investigating the genetic susceptibility to diabetic kidney disease. Together with investigators at The Broad Institute of Harvard and MIT, QUB and The University of Helsinki we have identified several novel genes implicated in diabetic kidney disease. Our efforts are focused on understanding how these genetic variants may contribute to disease susceptibility and or resistance with a view to developing therapeutic interventions and or dynamic biomarkers of susceptibility and disease progression. Interestingly many of the genetic variants implicated are associated with inflammatory processes.
The team comprises basic scientists, clinician investigators and bioinformaticians. We are part of the multidisciplinary Diabetes Complications Research Centre at UCD.