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Full NameDr Roisin Dwyer
- genetics, genomics and molecular biology
- cancer/oncology
- Medicine
- Surgery
- Pathology
- Endocrinology
- Oncology
- Physiology
Our research focuses on the primary breast tumour microenvironment in the context of cellular interactions, cytokine and exosome secretion, and pathways involved in disease progression. Understanding this environment facilitates harnessing the potential of Mesenchymal Stem Cells as vehicles for targeted delivery of therapy to breast tumours. In vivo imaging to track MSC migration is an important element of this, and includes novel approaches to imaging and therapy of breast tumours using radiolabelled iodide.
The work is multidisciplinary in nature, involving colleagues and collaborators in Surgery, Regenerative Medicine and Physics. We employ in vitro and in vivo models of breast cancer in parallel with patient samples, to identify biomarkers of disease, therapeutic targets, and methods to effectively monitor response to therapy. The work is translational in nature, performed by a team of clinicians and scientists. I have successfully mentored a number of clinicians through PhD studies in this programme.
References:
-Joyce DP, Kerin MJ and Dwyer RM. Exosome-encapsulated microRNAs as circulating biomarkers for breast cancer. Int J Cancer (2016) Oct 1;139(7):1443-8. PMID:27170104
-Dwyer RM et al. Mesenchymal Stem Cell mediated delivery of the Sodium Iodide Symporter supports radionuclide imaging and treatment of breast cancer. Stem Cells (2011) 29(7):1149-1157 PMID: 21608083