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Full NameProfessor Sabine Koelle
Department:School of Medicine
Organisation:University College Dublin
- cell and developmental biology/regenerative medicine
- physiology and non-communicable disease
Other Research Fields:
Postgrad Medical Specialties
- Obstetrics and Gynaecology
Other Medical Specialties:
Gynecology and Obstetrics, Andrology
Professor Koelle`s research is focused on reproductive medicine, especially on improving the results of assisted reproduction. In addition to that she is investigating the effects of diseases and medications on the early events of reproduction. Recent research projects include the mechanisms of gameto-maternal interaction, embryo-maternal communication and early embryogenesis in humans and animals and the alterations caused by diseases or medications. Additionally she is establishing new criteria for functional sperm and oocyte assessment and is developing new methods for in vivo imaging of fertilization and early embryogenesis in the female genital tract.
1. Leavy M, Trottmann M, Liedl B, Reese S, Stief C, Freitag B, Baugh J, Spagnoli C, Kölle S (2017). Effects of elevated beta estradiol levels on the functional morphology of the testis. Nature Scientific Reports 7:39931 | DOI: 10.1038/srep39931
2. O`Doherty A, Di Fenza M, Kölle S (2016): Lipopolysaccharide (LPS) disrupts particle transport, cilia function and sperm motility in an ex vivo oviduct model. Nature Scientific Reports 2016. doi: 10.1038/srep24583.
3. Trottmann M, Sroka R, Stepp H, Liedl B, Becker AJ, Stief CG, Kölle S (2016). Probe-based confocal laser endomicroscopy (pCLE): A preclinical investigation of the male genital tract. Lasers in Medical Science 31(1): 57-65.
4. Trottmann M, Kölle S, Leeb R, Doering D, Reese S, Stief CG, Dulohery K, Leavy M, Kuznetsova J, Homann C, Sroka R (2016). Ex vivo investigations on the potential of optical coherence tomography (OCT) as a diagnostic tool for reproductive medicine in a bovine model. J Biophotonics 9:129-137.
5. Trottmann M, Sroka R, Stepp H, Heide M, Liedl B, Reese S, Becker A, Stief CG, Kölle S (2015): Probe-based confocal laser endomicroscopy (pCLE) – a new imaging technique for in situ localization of spermatozoa. J Biophotonics 8: 415-421.
6. Kölle S (2015): Transport, distribution and elimination of mammalian sperm following natural mating and insemination. Reprod Dom Anim Suppl. 3: 2-6.
7. Pausch H, Kölle S, Wurmser C, Schwarzenbacher H, Ermmerling R, Jansen S, Trottmann M, Fürst C, Götz KU, Fries R (2014): A nonsense mutation in TMEM 95 encoding a nondescript transmembrane protein causes idiopathic male infertility in cattle. PLOS Genet 10(1):e 1004044.
A potential research project would be entitled “Endometriosis and its effects on early reproductive events – new insights by digital videomicroscopy and probe-based confocal laser endomicroscopy”. The project aims to investigate the alterations in the female genital tract induced by endometriosis using cutting-edge imaging technologies.
Endometriosis is characterized by growth of uterine tissue outside the uterus – in most patients the ovaries or the fallopian tube are affected. The main symptoms of this disease are pelvic pain and infertility. It might also cause dysmenorrhea, dyspareunia and dysuria. Endometriosis occurs in 6-10 % of the women, mainly in their thirties and forties. However, in the US, about 27 % of the women with endometriosis had had the symptoms for at least 6 years before it was diagnosed. In addition to that the precise cause for endometriosis is unknown to date – theories such as the retrograde menstruation theory or the theory of an autoimmune disease have not been able to explain all instances of endometriosis.
Therefore, the aim of the project is to shed light on the precise mechanisms of this disease by investigating the effects of tubal endometriosis on the functional integrity of the female genital tract. First, the effects of endometriosis on morphology and physiology of the fallopian tube will be analysed. Second, the effects of endometriosis on sperm-oviduct interaction as well as on the communication between oocyte and ampulla before and after fertilization will be examined. In the third step, the applicability of probe-based confocal laser endomicroscopy for application in routine diagnostic procedures will be evaluated. In summary, the ultimate goal of the project is to elucidate the precise mechanisms of endometriosis and to establish new diagnostic tools for this disease.