ICAT publications (March 2021)

ICAT Fellow activities (March 2021)
March 19, 2021
ICAT Alumni Update – David Mongan
September 28, 2021

Recent publications by ICAT Fellows (indicated in bold)

Walls GM, Cole AJ, Hanna GG, McAleer JJ. Local control: also a strength of radiotherapy training? R Coll (Clin Oncol) 2021:in press.

Bethany Wong, Sandra Redmond, Ciara Blaine, Carol-Ann Nugent, Lavanya Saiva, John Buckley, Jim O’Neill. Study of patients with iron deficiency and HF in Ireland: prevalence and treatment budget impact. March 2021, Br J Cardiol 2021;28:14–18, doi:10.5837/bjc.2021.010.

Townsend L, Dowds J, O’Brien K, Sheill G, Dyer AH, O’Kelly B, Hynes JP, Mooney A, Dunne J, Ni Cheallaigh C, O’Farrelly C, Bourke NM, Conlon N, Martin-Loeches I, Bergin C, Nadarajan P, Bannan C. Persistent Poor Health Post-COVID-19 Is Not Associated with Respiratory Complications or Initial Disease Severity. Ann Am Thorac Soc. 2021 Jan 8. doi: 10.1513/AnnalsATS.202009-1175OC. Epub ahead of print. PMID: 33413026.

Barrett PM. Adverse Pregnancy Outcomes—A Missed Opportunity to Prevent Chronic Disease? Int J Public Health. 2021 Jan 25. doi.org/10.3389/ijph.2021.582810.

Bowe AK, Doyle F, Stanistreet D, O’Connell E, Durcan M, Major E, O’Donovan D, Kavanagh P. E-Cigarette-Only and Dual Use among Adolescents in Ireland: Emerging Behaviours with Different Risk Profiles. International Journal of Environmental Research and Public Health. 2021; 18(1):332. https://doi.org/10.3390/ijerph18010332.

Mongan D, Yin X, Brennan L, Cotter D.. Dysregulation of lipid metabolism precedes psychosis… so is psychosis a metabolic disorder? Biological Psychiatry 2021 Feb 1; 89(3):209-211.

Doherty D, Lavin M, O’Sullivan JM, Ryan K, O’Connell NM, Dougall A, Byrne M, Rafferty M, Doyle MM, Di Paola J, James PD and O’Donnell JS. (2021), Management of elective procedures in low von Willebrand factor patients in the LoVIC study. J Thromb Haemost. https://doi.org/10.1111/jth.15220.

Walls G, Cole A, McAleer J et al. A Qualitative Assessment of Radiotherapy Training at a UK Regional Cancer Centre. R Coll (Clin Oncol) 2021:in press.

O’Connor C, O’Connell G, Nic Dhonncha E, Roche L, Quinlan C, Murphy LA, Gleeson C, Bennett M, Bourke J and Murphy M. (2021), Sense and sensibility: an Irish dermatology department in the era of COVID‐19. Clin Exp Dermatol. doi:10.1111/ced.14526.

Leacy E, Brady G, Conlon N, Scott J, Dunne J, Phelan T, McCormack WJ, Griffin MD, Kennedy A, Verrelli A, Molloy E, O’Sullivan D, Power J, Clarkson M, Zgaga L, O’Saughnessy M, Little MA. Study Protocol for DeCOmPRESS: Defining the Disease Course and Immune Profile of COVID-19 in the Immunosuppressed Patient. HRB Open Research 2021, 4:6, doi.org/10.12688/hrbopenres.13094.1.

CowhigC*, Scott J*, Dorman AM, Little MA, de Freitas DG. Acute renal allograft failure in a patient with vasculitis. Rheumatology 2021 (In Press). (*joint contributions)

Thompson HA, Mousa A, Dighe A, Fu H, Arnedo-Pena A, Barrett P et al. SARS-CoV-2 setting-specific transmission rates: a systematic review and meta-analysis. Clin Infect Dis. 2021 Feb 9:ciab100. doi: 10.1093/cid/ciab100.

Barrett S, Simpkin A, Walls G et al. Geometric and Dosimetric Evaluation of a Commercially Available Auto-segmentation Tool for Gross Tumour Volume Delineation in Locally Advanced Non-small Cell Lung Cancer: a Feasibility Study. R Coll (Clin Oncol) 2021;33(3):155-162.

Singh U, Walls G, Hanna G, et al. PET/CT features of lung SABR chest wall toxicity. J Med Imaging Radiat Oncol 2021:65:92-94.

O’Sullivan G, Jacob S, Barrett PM, Gallagher J. Covid-19 presentation among symptomatic healthcare workers in Ireland. Occup Med (Lond). 2021 Feb 15;kqab012. doi: 10.1093/occmed/kqab012.

Evison M, Barrett E, Cheng A, Mulla A, Walls G et al. Predicting the Risk of Disease Recurrence and Death Following Curative-intent Radiotherapy for Non-small Cell Lung Cancer: The Development and Validation of Two Scoring Systems From a Large Multicentre UK Cohort. R Coll (Clin Oncol) 2021;33(3):145-154.

Susai SR, Sabherwal S, Mongan D, Föcking M, Cotter D. Omega-3 Fatty acids in Ultra high-risk psychosis: A systematic review based on functional outcome. Early Intervention in Psychiatry (accepted for publication 2021 Jan 31).

Kundu S, Gurney M, O’Dwyer M. Generating natural killer cells for adoptive transfer: expanding horizons. Cytotherapy. 2021 Jan 8:S1465-3249(20)30966-X. doi: 10.1016/j.jcyt.2020.12.002. Epub ahead of print. PMID: 33431318.

Benson KA, Murray SL, Senum, SR, Elhassan E, Conlon ET, Kennedy C, Conlon S, Gilbert E, Connaughton D, O’Hara P, Khamis S, Cormican S, Brody LC, Molloy AM, Lynch SA, Casserly L, Griffin MD, Carton R, Yachnin K, Harris PC, Cavalleri GL, Conlon PC. The genetic landscape of polycystic kidney disease in Ireland. Eur J Hum Genet (2021). https://doi.org/10.1038/s41431-020-00806-5.

Kelly B, Judge C, Bollard SM, Clifford SM, Healy GM, Yeom KW, Lawlor A, Killeen RP. Radiology artificial intelligence, a systematic evaluation of methods (RAISE): a systematic review protocol. Insights into imaging. 2020 Dec;11(1):1-6.

Gurney M, Stikvoort A, Nolan E, Kirkham-Mccarthy L, Khoruzhenko S, Shivakumar R, Zweegman S, Van De Donk NWCJ, Mutis T, Szegezdi E, et al. CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide. Haematologica 2020, 105, doi:10.3324/haematol.2020.271908.

Bowe AK, Healy C, Cannon M, Codd MB. Physical activity and emotional-behavioural difficulties in young people: a longitudinal population-based cohort study [published online ahead of print, 2020 Nov 11]. Eur J Public Health. 2020; ckaa182. doi:10.1093/eurpub/ckaa182

Mongan D, Föcking M, Healy C et al. Development of proteomic prediction models for transition to psychotic disorder in the clinical high-risk state and psychotic experiences in adolescence. JAMA Psychiatry 2020 Aug 26: e202459.

Loughlin EA, Judge CS, Gorey SE, Costello MM, Murphy RP, Waters RF, Hughes DS, Kenny RA, O’Donnell MJ, Canavan MD. Increased Salt Intake for Orthostatic Intolerance Syndromes: A Systematic Review and Meta-Analysis. The American Journal of Medicine. 2020 Dec 1;133(12):1471-8.

O’Connor C, Gallagher C, Dunphy M, Paul L, and O’Connell M. (2020), Irish patients with psoriasis have poor awareness of their risk of ischemic heart disease and inflammatory bowel disease. Int. J. Dermatol. doi:10.1111/ijd.15213.

Mongan D, Cannon M, Cotter D. COVID-19, hypercoagulation and what it could mean for patients with psychotic disorders. Brain, Behavior, and Immunity. 2020 Aug; 88: 9–10.

Judge C, O’Donnell MJ, Hankey GJ, Rangarajan S, Chin SL, Rao-Melacini P, Ferguson J, Smyth A, Xavier D, Lisheng L, Zhang H. Urinary Sodium and Potassium, and Risk of Ischaemic and Haemorrhagic Stroke (INTERSTROKE): a case-control study. American journal of hypertension. 2020 Nov 17.

Mongan D, Sabherwal S, Susai SR, Föcking M, Cannon M, Cotter D. Peripheral complement proteins in schizophrenia: A systematic review and meta-analysis of serological studies. Schizophrenia Research 2020 Aug; 222:58-72.

G Greenfield, S McPherson, J Smith, A Mead, C Harrison, K Mills, MF McMullin. Modification of the Histone Landscape with JAK Inhibition in Myeloproliferative Neoplasms. Cancers 2020 12(9), 2669

Ward SE, Curley GF, Lavin M, Fogarty H, Karampini E, McEvoy NL, Clarke J, Boylan M, Alalqam R, Worrall AP, Kelly C, de Barra E, Glavey S, Ni Cheallaigh C, Bergin C, Martin-Loeches I, Townsend L, Mallon PW, O’Sullivan JM, O’Donnell JS; Irish COVID-19 Vasculopathy Study (ICVS) Investigators. Von Willebrand factor propeptide in severe coronavirus disease 2019 (COVID-19): evidence of acute and sustained endothelial cell activation. Br J Haematol. 2020 Dec 16. doi: 10.1111/bjh.17273. PMID: 33326604.

Murphy R, McGrath E, Nolan A, Smyth A, Canavan M, O’Donnell M, Judge C. The impact of a run-in period on treatment effects in cardiovascular prevention randomised control trials: A protocol for a comprehensive review and meta-analysis. HRB Open Research. 2020 Nov 11;3(82):82.

O’Connor C, Courtney C, and Murphy M. (2020) Shedding light on the myths of ultraviolet radiation in the Covid-19 pandemic. Clinical and Experimental Dermatology. doi: 10.1111/ced.14456.

O’Connor C, Jordan E, O’Connell M. (2020). Atypical Stevens-Johnson syndrome caused by pembrolizumab in the treatment of metastatic melanoma – are corticosteroids a safe treatment option? J Dermatol Dermatol Surg, 24:137-9 doi:10.4103/jdds.jdds_73_20.

Murphy RP, Dennehy KA, Costello MM, Murphy EP, Judge CS, O’Donnell MJ, Canavan MD. Virtual geriatric clinics and the COVID-19 catalyst: a rapid review. Age and ageing. 2020 Nov;49(6):907-14

O Michail, P McCallion, J McGimpsey, A Hindley, G Greenfield, J Feerick, C Arnold, N Cross, R Cuthbert, MF McMullin, M Catherwood. Mutational profiling in suspected triple-negative essential thrombocythaemia using targeted next-generation sequencing in a real-world cohort. Journal of Clinical Pathology 2020.

Judge C, Hughes D, Canavan M. Replicability of Treatment Effect in Study of Blood Pressure Lowering With Dementia—Reply. Jama. 2020 Oct 13;324(14):1466-7

Ravikumar, N., & Greenfield, G. (2020). Glucose-6-phosphate Dehydrogenase Deficiency: A Review. International Journal of Medical Students, 8(3), 281-287.

Martin WP, le Roux CW, Docherty NG. Impact of metabolic surgery on renal injury in pre-clinical models of diabetic kidney disease. Nephron 2020 Dec 2; 1-10. DOI: 10.1159/000511790; PMID: 33264793.

Costello M, Judge C, O’Donnell MJ, Canavan M. Response to letter: non‐vitamin‐K oral anticoagulants may not significantly reduce the risk of fatal or disabling stroke compared with warfarin. European Journal of Neurology. 2020 Oct;27(10):e56-.

Martin WP, Tuohy C, Doody A, Jackson S, Canavan RJ, Slattery D, Twomey PJ, McKenna MJ, le Roux CW, Docherty NG. Parallel assessment of albuminuria and plasma sTNFR1 in people with type 2 diabetes and advanced chronic kidney disease provides accurate prognostication of the risks of renal decline and death. Sci Rep. 2020 Sep, 10(1): 14852. PMID: 32908199. DOI: 10.1038/s41598-020-71684-6.

Martin WP, Bauer J, Coleman J, Dellatorre-Teixeira L, Reeve JL, Twomey PJ, Docherty NG, O’Riordan A, Watson AJ, le Roux CW, Holian J. Obesity is common in chronic kidney disease and associates with greater antihypertensive usage and proteinuria: evidence from a cross-sectional study in a tertiary nephrology centre. Clin Obes. 2020 Aug, e12402. PMID: 32845571. DOI: 10.1111/cob.12402.

Martin WP, White J, López-Hernández F, Docherty NG, le Roux CW. Metabolic surgery to treat obesity in diabetic kidney disease, chronic kidney disease, and end-stage kidney disease; what are the unanswered questions? Frontiers in Endocrinology. 2020 April; 11, 289. doi: 10.3389/fendo.2020.00289. PMID: 33013677; PMCID: PMC7462008.

Martin WP, le Roux CW. Can metabolic surgery be used to improve access to and outcomes of kidney transplantation? Obesity 2020 Dec; 28 (12): 2259. PMID: 33230960; PMCID: PMC7116467; DOI: 10.1002/oby.23052.

Nair M, Martin WP, Zhernovkov V, Fearon N, Elliott JA, Eckhardt HG, McCormack J, Godson C, Brennan EP, Fandriks L, Docherty NG, le Roux CW. Characterisation of the renal cortical transcriptome following Roux-en-Y gastric bypass surgery in experimental diabetic kidney disease. BMJ Open Diabetes Res Care 2020 Jul; 8(1): e001113. PMID: 32747384. PMCID: PMC7398104. DOI: 10.1136/bmjdrc-2019-001113.

Silveira FC, Martin WP, le Roux CW, Ren-Fielding CJ. The impact of chronic kidney disease on perioperative risk and mortality after bariatric surgery. Kidney360 2020 Dec. DOI: https://doi.org/10.34067/KID.0004832020.

Grannell A, Martin WP, Dehestani B, Al-Najim W, Murphy JC, le Roux CW. Liraglutide does not adversely impact fat-free mass loss. Obesity 2021 Feb. doi: 10.1002/oby.23098.

Judge C, Murphy RP, Cormican S, Smyth A, O’Halloran M, O’Donnell M. Adaptive design methods in dialysis clinical trials: a systematic review protocol. BMJ Open 2020; 10:e036755. doi: 10.1136/bmjopen-2019-036755.

Barrett PM, McCarthy FP, Evans M, Kublickas M, Perry IJ, Stenvinkel P, Khashan AS, Kublickiene K. Hypertensive disorders of pregnancy and the risk of chronic kidney disease: A Swedish registry-based cohort study. PLoS Med. 2020 Aug 14;17(8):e1003255. doi: 10.1371/journal.pmed.1003255. eCollection 2020 Aug.

Barrett PM, Khashan AS, McCarthy FP, Kublickiene K. Adverse pregnancy outcomes and maternal health: Action needed for long-term benefit. Acta Obstet Gynecol Scand. 2020 Sep;99(9):1107-1109. doi: 10.1111/aogs.13945.

Barrett PM, Mullen L, McCarthy T. Enduring psychological impact of childhood cancer on survivors and their families in Ireland: A national qualitative study. Eur J Cancer Care (Engl). 2020 Sep;29(5):e13257. doi: 10.1111/ecc.13257. Epub 2020 Jun 15.

Barrett PM, Bambury N, Kelly L, Condon R, Crompton J, Sheahan A. Measuring the effectiveness of an automated text messaging active surveillance system for COVID-19 in the south of Ireland, March to April 2020. Euro Surveill. 2020 Jun;25(23):2000972. doi: 10.2807/1560-7917.ES.2020.25.23.2000972.

Carey C, O’Donnell K, Davoren M, Quinlan M, Igoe D, Barrett P. Factors associated with lower knowledge of HIV and STI transmission, testing and treatment among MSM in Ireland: findings from the MSM Internet Survey Ireland (MISI) 2015. Sex Transm Infect. 2020 Oct 26:sextrans-2020-054469. doi: 10.1136/sextrans-2020-054469.