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Full NameDr David Clarke
- infectious disease and the immune system
- Medicine
- Pathology
- Gastroenterology
- Infectious diseases
- Immunology
My lab is interested in unraveling the molecular mechanisms that underpin bacteria-host interactions. One of our research interests focuses on understanding the genetic requirements for the formation of a healthy gut microbiome. To this end we are using 2 important Gram-negative, commensal (i.e. beneficial) bacteria that colonise the human gut as model systems; Escherichia coli and Bacteroides thetaiotamicron.
Using a number of recently developed molecular-based approaches (based on next-generation sequencing and high-resolution transposon mutagenesis) we are currently undertaking global screens to identify factors that are important for the establishment of these bacteria in the mammalian gut. It is hoped that these studies will provide a comprehensive genetic framework to facilitate a rationale-based approach towards the development of gut-targeted biotherapeutics that will support improved human health.